YCK1/YHR135C Protein Information 
| Standard Name | Yck1p |
|---|---|
| Systematic Name | Yhr135cp |
| Alias | Cki2p |
| ORF Classification | Verified |
| Description | Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK1 has a paralog, YCK2, that arose from the whole genome duplication (1, 10, 2, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Yeast Casein Kinase I homologue 5 |
| Experimental Data | |
|---|---|
| Molecules/cell | 1630 11 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Yck1p (InterPro) |
| Physical Interactions | There are 361 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000004F9F7 | P23291 MIPS: YHR135C NCBI: 140436 | 173208 | 2231066 | 433624 | 500684 | 51830384 | 6321927 | NP_012003.1 | NM_001179265.1 GenBank/EMBL/DDBJ: DAA06828.1 | AY723826 | M74552 | U10398 | X60327 | Y13625 |
| External Classifications | EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] |
external links for Yck1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| YGOB | BioPIXIE | MIPS | YeastGFP |
| YOGY | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Complexome | YeastRC Structure Prediction (Seattle) | ||
| DIP | |||
| GeneMANIA | |||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Yck1p
| 1) | Marchal C, et al. (2000) Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease. J Biol Chem 275(31):23608-14 |
| 2) | Hicke L, et al. (1998) Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization. J Cell Biol 141(2):349-58 |
| 3) | Wang PC, et al. (1992) Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1. Mol Biol Cell 3(3):275-86 |
| 4) | Robinson LC, et al. (1993) Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis. Mol Cell Biol 13(5):2870-81 |
| 5) | Robinson LC, et al. (1992) Yeast casein kinase I homologues: an essential gene pair. Proc Natl Acad Sci U S A 89(1):28-32 |
| 6) | Robinson LC, et al. (1999) The Yck2 yeast casein kinase 1 isoform shows cell cycle-specific localization to sites of polarized growth and is required for proper septin organization. Mol Biol Cell 10(4):1077-92 |
| 7) | Feng Y and Davis NG (2000) Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane. Mol Cell Biol 20(14):5350-9 |
| 8) | Roth AF, et al. (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 159(1):23-8 |
| 9) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 10) | Reddi AR and Culotta VC (2013) SOD1 integrates signals from oxygen and glucose to repress respiration. Cell 152(1-2):224-35 |
| 11) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
