ARP1/YHR129C Protein Information

Standard Name	Arp1p 1
Systematic Name	Yhr129cp
Alias	Act5p 2
ORF Classification	Verified
Description	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin (2, 3)
Name Description	Actin-Related Protein

Experimental Data
Molecules/cell	1580 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	384
Molecular Weight (Da)	42,995
Isoelectric Point (pI)	5.26

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arp1p (InterPro)
Physical Interactions	There are 30 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000126051 \| P38696 MIPS: YHR129C NCBI: 500679 \| 51013619 \| 557670 \| 6321921 \| 728795 \| NP_011997.1 GenBank/EMBL/DDBJ: DAA06822.1 \| AY693084 \| U10398 \| X79811

Amino Acid Sequence (or in FASTA format)
1 MDQLSDSYAL YNQPVVIDNG SGIIKAGFSG EERPKALEYC LVGNTKYDKV 51 MLEGLQGDTF IGNNAQKLRG LLKLRYPIKH GVVEDWDSME LIWSYVLNEV 101 LQLQNIGEHP LLITEAPMNP LKNREQMAQV LFETFDVSAL YVSNPAVLSL 151 YASGRTTGCV VDCGEGYCST VPIYDGFALP ASMMRMDIGG ADITEQLQFQ 201 LRKSAGVSLF SSSEREIVRT MKEKVCYLAK NIKKEEEKYL QGTQDLISTF 251 KLPDGRCIEV GNDRYRAPEI LFSPQIIGLG YDGLSDMCMQ SIWKVDLDLR 301 KPLLSSIILS GGTTTLKGFG DRMLWDLEAL TKGTSKIKII APSERKYTTW 351 IGGSILTGLS TFQRLWTKKS DWLEDSTRVY SNLM*

Amino Acid Sequence (or in FASTA format)

       1  MDQLSDSYAL YNQPVVIDNG SGIIKAGFSG EERPKALEYC LVGNTKYDKV
      51  MLEGLQGDTF IGNNAQKLRG LLKLRYPIKH GVVEDWDSME LIWSYVLNEV
     101  LQLQNIGEHP LLITEAPMNP LKNREQMAQV LFETFDVSAL YVSNPAVLSL
     151  YASGRTTGCV VDCGEGYCST VPIYDGFALP ASMMRMDIGG ADITEQLQFQ
     201  LRKSAGVSLF SSSEREIVRT MKEKVCYLAK NIKKEEEKYL QGTQDLISTF
     251  KLPDGRCIEV GNDRYRAPEI LFSPQIIGLG YDGLSDMCMQ SIWKVDLDLR
     301  KPLLSSIILS GGTTTLKGFG DRMLWDLEAL TKGTSKIKII APSERKYTTW
     351  IGGSILTGLS TFQRLWTKKS DWLEDSTRVY SNLM*

external links for Arp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Arp1p

1)	Poch O and Winsor B (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
2)	Muhua L, et al. (1994) A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Cell 78(4):669-79
3)	Clark SW and Meyer DI (1994) ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. J Cell Biol 127(1):129-38
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41