CIA2/YHR122W Protein Information

Standard Name	Cia2p 1, 2
Systematic Name	Yhr122wp
ORF Classification	Verified
Description	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B (2)
Name Description	Cytosolic Iron-sulfur protein Assembly 1

Experimental Data
Molecules/cell	1800 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	231
Molecular Weight (Da)	25,675
Isoelectric Point (pI)	4.39

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cia2p (InterPro)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531D5 \| P38829 MIPS: YHR122W NCBI: 500677 \| 6321914 \| 731709 \| NP_011990.1 GenBank/EMBL/DDBJ: DAA06816.1 \| U10398

Amino Acid Sequence (or in FASTA format)
1 MSEFLNENPD ILEENQLPTR KEDSTKDLLL GGFSNEATLE RRSLLLKIDH 51 SLKSQVLQDI EVLDKLLSIR IPPELTSDED SLPAESEDES VAGGGKEEEE 101 PDLIDAQEIY DLIAHISDPE HPLSLGQLSV VNLEDIDVHD SGNQNEMAEV 151 VIKITPTITH CSLATLIGLG IRVRLERSLP PRFRITILLK KGTHDSENQV 201 NKQLNDKERV AAACENEQLL GVVSKMLVTC K*

Amino Acid Sequence (or in FASTA format)

       1  MSEFLNENPD ILEENQLPTR KEDSTKDLLL GGFSNEATLE RRSLLLKIDH
      51  SLKSQVLQDI EVLDKLLSIR IPPELTSDED SLPAESEDES VAGGGKEEEE
     101  PDLIDAQEIY DLIAHISDPE HPLSLGQLSV VNLEDIDVHD SGNQNEMAEV
     151  VIKITPTITH CSLATLIGLG IRVRLERSLP PRFRITILLK KGTHDSENQV
     201  NKQLNDKERV AAACENEQLL GVVSKMLVTC K*

external links for Cia2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cia2p

1)	Mascarenhas J and Lill R (2011) Cia2 is essential for iron-sulfur cluster insertion ()
2)	Stehling O, et al. (2012) MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337(6091):195-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41