MSH1/YHR120W Protein Information Help

Standard Name Msh1p 1
Systematic Name Yhr120wp
ORF Classification Verified
Description DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis (1, 2, 3)
Name Description MutS Homolog 1
Experimental Data
Molecules/cell 1670 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 959
Molecular Weight (Da) 109,407
Isoelectric Point (pI) 9.13

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msh1p (InterPro)
Physical Interactions There are 23 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F5EC | P25846
MIPS: YHR120W
NCBI: 172000 | 529134 | 6321912 | 730065 | NP_011988.1 | NM_001179250.1
GenBank/EMBL/DDBJ: AAA34801.1 | AAB68849.1 | DAA06814.1 | M84169 | U00059
Amino Acid Sequence (or in FASTA format)
       1  MKHFFRLPTA FRPISRVSLR YSSTDTAQPK ISKLKISFNK ISESNSEKKD
      51  NLGSIDTRNC LSTQQDDKLS STEPSKASLP PSLQYVRDLM DLYKDHVVLT
     101  QMGSFYELYF EQAIRYAPEL NISLTNRAYS HGKVPFAGFP VHQLSRHLKM
     151  LVNNCGYSVT IAEQFKKKDV ADNEANKFYR RVTRIVTPGT FIDEAFENLR
     201  ENTYLLNIEF PENCMSQVAD TSLKVGICWC DVSTGEIFVQ QVYLRDLVSA
     251  ITRIQPKEIL LDERLLEFHI ESGTWYPELV ELKKFFIKYQ KMPSQHRTIE
     301  SFYGLFNLGG KEATERQLKI QFQTFTQKEL AALRNTLIYV SNHLPDFSIN
     351  FQIPQRQLAT AIMQIDSRTS TALELHSTVR DNNKKGSLLS SIRRTVTPSG
     401  TRLLSQWLSG PSLDLKEIKK RQKIVAFFKD NRDITETLRT MLKKVNDLSR
     451  ILQKFSFGRG EALELIQMAR SLEVSREIRK YLLNNTSLMK ATLKSQITQL
     501  TESLNFEKNL IDDILKFLNE EELAKSQDAK QNADVTRMLD IDVKDKKESN
     551  KDEIFELRDF IVNPSFNTKL RKLHDTYQGV WQKKTEYNAL LKGFFVGDLG
     601  AKTFTLKERQ NGEYALHVTG TASSLKKIDE LISKSTEYHG SCFHILQKSS
     651  QTRWLSHKIW TDLGHELELL NLKIRNEEAN IIDLFKRKFI DRSNEVRQVA
     701  TTLGYLDTLS SFAVLANERN LVCPKVDESN KLEVVNGRHL MVEEGLSARS
     751  LETFTANNCE LAKDNLWVIT GPNMGGKSTF LRQNAIIVIL AQIGCFVPCS
     801  KARVGIVDKL FSRVGSADDL YNEMSTFMVE MIETSFILQG ATERSLAILD
     851  EIGRGTSGKE GISIAYATLK YLLENNQCRT LFATHFGQEL KQIIDNKCSK
     901  GMSEKVKFYQ SGITDLGGNN FCYNHKLKPG ICTKSDAIRV AELAGFPMEA
     951  LKEAREILG*                                            

external links for Msh1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Msh1p
1) Reenan RA and Kolodner RD  (1992) Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics 132(4):963-73
2) Chi NW and Kolodner RD  (1994) The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. J Biol Chem 269(47):29993-7
3) Meyer C, et al.  (2001) Transcription of mutS- and mutL-homologous genes during meiosis in Saccharomyces cerevisiae and identification of a regulatory cis-element for meiotic induction of MSH2. Mol Genet Genomics 265(5):826-36
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41