CDC12/YHR107C Protein Information

Standard Name	Cdc12p
Systematic Name	Yhr107cp
Alias	Cla10p , Psl7p
ORF Classification	Verified
Description	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells (1, 2, 3, 4, 5, 6)
Name Description	Cell Division Cycle 7

Experimental Data
Molecules/cell	1170 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	407
Molecular Weight (Da)	46,668
Isoelectric Point (pI)	8.17

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cdc12p (InterPro)
Physical Interactions	There are 153 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F44 \| P32468 MIPS: YHR107C NCBI: 416761 \| 473769 \| 529130 \| 575397 \| 6321899 \| NP_011975.1 GenBank/EMBL/DDBJ: DAA06801.1 \| L16551 \| U00059 \| X82498

Amino Acid Sequence (or in FASTA format)
1 MSAATATAAP VPPPVGISNL PNQRYKIVNE EGGTFTVMLC GESGLGKTTF 51 INTLFQTVLK RADGQQHRQE PIRKTVEIDI TRALLEEKHF ELRVNVIDTP 101 GFGDNVNNNK AWQPLVDFID DQHDSYMRQE QQPYRTKKFD LRVHAVLYFI 151 RPTGHGLKPI DIETMKRLST RANLIPVIAK ADTLTAQELQ QFKSRIRQVI 201 EAQEIRIFTP PLDADSKEDA KSGSNPDSAA VEHARQLIEA MPFAIVGSEK 251 KFDNGQGTQV VARKYPWGLV EIENDSHCDF RKLRALLLRT YLLDLISTTQ 301 EMHYETYRRL RLEGHENTGE GNEDFTLPAI APARKLSHNP RYKEEENALK 351 KYFTDQVKAE EQRFRQWEQN IVNERIRLNG DLEEIQGKVK KLEEQVKSLQ 401 VKKSHLK*

Amino Acid Sequence (or in FASTA format)

       1  MSAATATAAP VPPPVGISNL PNQRYKIVNE EGGTFTVMLC GESGLGKTTF
      51  INTLFQTVLK RADGQQHRQE PIRKTVEIDI TRALLEEKHF ELRVNVIDTP
     101  GFGDNVNNNK AWQPLVDFID DQHDSYMRQE QQPYRTKKFD LRVHAVLYFI
     151  RPTGHGLKPI DIETMKRLST RANLIPVIAK ADTLTAQELQ QFKSRIRQVI
     201  EAQEIRIFTP PLDADSKEDA KSGSNPDSAA VEHARQLIEA MPFAIVGSEK
     251  KFDNGQGTQV VARKYPWGLV EIENDSHCDF RKLRALLLRT YLLDLISTTQ
     301  EMHYETYRRL RLEGHENTGE GNEDFTLPAI APARKLSHNP RYKEEENALK
     351  KYFTDQVKAE EQRFRQWEQN IVNERIRLNG DLEEIQGKVK KLEEQVKSLQ
     401  VKKSHLK*

external links for Cdc12p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cdc12p

1)	Takizawa PA, et al. (2000) Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290(5490):341-4
2)	Gladfelter AS, et al. (2001) The septin cortex at the yeast mother-bud neck. Curr Opin Microbiol 4(6):681-9
3)	Hanrahan J and Snyder M (2003) Cytoskeletal activation of a checkpoint kinase. Mol Cell 12(3):663-73
4)	Versele M, et al. (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 15(10):4568-83
5)	Vrabioiu AM, et al. (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem 279(4):3111-8
6)	McMurray MA, et al. (2011) Septin filament formation is essential in budding yeast. Dev Cell 20(4):540-9
7)	Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41