KIC1/YHR102W Protein Information Help

Standard Name Kic1p 1
Systematic Name Yhr102wp
Alias Nrk1p
ORF Classification Verified
Description Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis (1, 2)
Name Description Kinase that Interacts with Cdc31p 1
Experimental Data
Molecules/cell 1040 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,080
Molecular Weight (Da) 117,060
Isoelectric Point (pI) 8.08

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kic1p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000130510 | P38692
MIPS: YHR102W
NCBI: 529127 | 6321894 | 729897 | 836813 | NP_011970.1
GenBank/EMBL/DDBJ: DAA06796.1 | D29980 | U00059
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTTKPQNSKQ GLAEGEMDVS SLFKRTEVIG RGKFGVVYKG YNVKTGRVYA
      51  IKVLNLDSDS DEVEDVQREI QFLASLKQIS NITRYYGSYL KDTSLWIIME
     101  HCAGGSLRSL LRPGKIDEKY IGVIMRELLV ALKCIHKDNV IHRDIKAANV
     151  LITNEGNVKL CDFGVAAQVN QTSLRRQTMA GTPYWMAPEV IMEGVYYDTK
     201  VDIWSLGITT YEIATGNPPY CDVEALRAMQ LIIKSKPPRL EDRSYSTSLK
     251  EFIALCLDED PKERLSADDL LKSKFIRAHK ATPTSILKEL ISRYLLFRDK
     301  NKNKYKIEGS IPENEPSKPS EAPKPSQNGG GDEAQKSIAS NDNEIKRVNE
     351  GDVEMKWDFD SLSSSDYIIE NNINLDALAE DNNEWATAQH DLFNYAYPDE
     401  DSYYFDPTSH NTRPFVYQGT TIGKGYPGTI AQNSTLNAPV TNNYTNSKYP
     451  SKMVAGTTNT SGTHTAGPMT SSKRLESKAP KQLLELFEDN EIITAENDVN
     501  TEAPKISKSI SSLNAGNSSR DDFIPSISNE VNGNINNNKM RPHLPPLSSG
     551  NNYYSQSTPA LPLLQTKFNK TSKGPPTSGL TTAPTSIEIE IPEELPNSAL
     601  PTPASADPVL IPSTKARSST VTAGTPSSSS SIQYKSPSNV PRRLTVSNNR
     651  PEHCPSTITN QKLGSAVASN SGISSTPNNS NNYNNNTDSE NSRGSSGSNT
     701  ANSTQMGITN PGNVTKLSTH KASSPSRPLF GVGTSPNRKP AGSPTQNIGH
     751  NSTHTNLAPP PTMKPMANSK DNKDILLQPL NSIPSSSTLN TISGNSSNNL
     801  TSSNYFSNEK EGSRVNGDFK RNNPNLKLQM PLPTPVVRNK LLDPNTATSQ
     851  NNNGMPGSAG ISTNENINQF GFNTSSASNI PVSMTPISEK HIDFGGKIKR
     901  SQSISNRKNS SASEHPLNIL GSSVSGNVSG IGNNNVGSNN NSGPNNSVPL
     951  SANTGNTTIK ANSTTIATSS SAAASTTAPI SQQTIPSGTQ FNHILSSAAT
    1001  AANSVNSLGF GMCPPPQSLQ MEMFLDLESF LPGKQRRVDR KPQVLKELEN
    1051  LLQMFEEGLP CIEHALKEQL ISTPIKDNEH *

external links for Kic1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Kic1p
1) Sullivan DS, et al.  (1998) The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. J Cell Biol 143(3):751-65
2) Nelson B, et al.  (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41