TRA1/YHR099W Protein Information

Standard Name	Tra1p 1, 2
Systematic Name	Yhr099wp
ORF Classification	Verified
Description	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation (1, 2, 3, 4)
Name Description	similar to human TRRAP 1, 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	3,744
Molecular Weight (Da)	433,175
Isoelectric Point (pI)	6.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tra1p (InterPro)
Physical Interactions	There are 236 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B2B9 \| P38811 MIPS: YHR099W NCBI: 487929 \| 6321891 \| 731689 \| NP_011967.1 \| NM_001179229.1 GenBank/EMBL/DDBJ: DAA06793.1 \| U00060

Amino Acid Sequence (or in FASTA format)
1 MSLTEQIEQF ASRFRDDDAT LQSRYSTLSE LYDIMELLNS PEDYHFFLQA 51 VIPLLLNQLK EVPISYDAHS PEQKLRNSML DIFNRCLMNQ TFQPYAMEVL 101 EFLLSVLPKE NEENGILCMK VLTTLFKSFK SILQDKLDSF IRIIIQIYKN 151 TPNLINQTFY EAGKAEQGDL DSPKEPQADE LLDEFSKNDE EKDFPSKQSS 201 TEPRFENSTS SNGLRSSMFS FKILSECPIT MVTLYSSYKQ LTSTSLPEFT 251 PLIMNLLNIQ IKQQQEAREQ AESRGEHFTS ISTEIINRPA YCDFILAQIK 301 ATSFLAYVFI RGYAPEFLQD YVNFVPDLII RLLQDCPSEL SSARKELLHA 351 TRHILSTNYK KLFLPKLDYL FDERILIGNG FTMHETLRPL AYSTVADFIH 401 NIRSELQLSE IEKTIKIYTG YLLDESLALT VQIMSAKLLL NLVERILKLG 451 KENPQEAPRA KKLLMIIIDS YMNRFKTLNR QYDTIMKYYG RYETHKKEKA 501 EKLKNSIQDN DKESEEFMRK VLEPSDDDHL MPQPKKEDIN DSPDVEMTES 551 DKVVKNDVEM FDIKNYAPIL LLPTPTNDPI KDAFYLYRTL MSFLKTIIHD 601 LKVFNPPPNE YTVANPKLWA SVSRVFSYEE VIVFKDLFHE CIIGLKFFKD 651 HNEKLSPETT KKHFDISMPS LPVSATKDAR ELMDYLAFMF MQMDNATFNE 701 IIEQELPFVY ERMLEDSGLL HVAQSFLTSE ITSPNFAGIL LRFLKGKLKD 751 LGNVDFNTSN VLIRLFKLSF MSVNLFPNIN EVVLLPHLND LILNSLKYST 801 TAEEPLVYFY LIRTLFRSIG GGRFENLYRS IKPILQVLLQ SLNQMILTAR 851 LPHERELYVE LCITVPVRLS VLAPYLPFLM KPLVFALQQY PDLVSQGLRT 901 LELCIDNLTA EYFDPIIEPV IDDVSKALFN LLQPQPFNHA ISHNVVRILG 951 KLGGRNRQFL KPPTDLTEKT ELDIDAIADF KINGMPEDVP LSVTPGIQSA 1001 LNILQSYKSD IHYRKSAYKY LTCVLLLMTK SSAEFPTNYT ELLKTAVNSI 1051 KLERIGIEKN FDLEPTVNKR DYSNQENLFL RLLESVFYAT SIKELKDDAM 1101 DLLNNLLDHF CLLQVNTTLL NKRNYNGTFN IDLKNPNFML DSSLILDAIP 1151 FALSYYIPEV REVGVLAYKR IYEKSCLIYG EELALSHSFI PELAKQFIHL 1201 CYDETYYNKR GGVLGIKVLI DNVKSSSVFL KKYQYNLANG LLFVLKDTQS 1251 EAPSAITDSA EKLLIDLLSI TFADVKEEDL GNKVLENTLT DIVCELSNAN 1301 PKVRNACQKS LHTISNLTGI PIVKLMDHSK QFLLSPIFAK PLRALPFTMQ 1351 IGNVDAITFC LSLPNTFLTF NEELFRLLQE SIVLADAEDE SLSTNIQKTT 1401 EYSTSEQLVQ LRIACIKLLA IALKNEEFAT AQQGNIRIRI LAVFFKTMLK 1451 TSPEIINTTY EALKGSLAEN SKLPKELLQN GLKPLLMNLS DHQKLTVPGL 1501 DALSKLLELL IAYFKVEIGR KLLDHLTAWC RVEVLDTLFG QDLAEQMPTK 1551 IIVSIINIFH LLPPQADMFL NDLLLKVMLL ERKLRLQLDS PFRTPLARYL 1601 NRFHNPVTEY FKKNMTLRQL VLFMCNIVQR PEAKELAEDF EKELDNFYDF 1651 YISNIPKNQV RVVSFFTNMV DLFNTMVITN GDEWLKKKGN MILKLKDMLN 1701 LTLKTIKENS FYIDHLQLNQ SIAKFQALYL RFTELSERDQ NPLLLDFIDF 1751 SFSNGIKASY SLKKFIFHNI IASSNKEKQN NFINDATLFV LSDKCLDARI 1801 FVLKNVINST LIYEVATSGS LKSYLVEDKK PKWLELLHNK IWKNSNAILA 1851 YDVLDHHDLF RFELLQLSAI FIKADPEIIA EIKKDIIKFC WNFIKLEDTL 1901 IKQSAYLVTS YFISKFDFPI KVVTQVFVAL LRSSHVEARY LVKQSLDVLT 1951 PVLHERMNAA GTPDTWINWV KRVMVENSSS QNNILYQFLI SHPDLFFNSR 2001 DLFISNIIHH MNKITFMSNS NSDSHTLAID LASLILYWEN KTLEITNVNN 2051 TKTDSDGDVV MSDSKSDINP VEADTTAIIV DANNNSPISL HLREACTAFL 2101 IRYVCASNHR AIETELGLRA INILSELISD KHWTNVNVKL VYFEKFLIFQ 2151 DLDSENILYY CMNALDVLYV FFKNKTKEWI MENLPTIQNL LEKCIKSDHH 2201 DVQEALQKVL QVIMKAIKAQ GVSVIIEEES PGKTFIQMLT SVITQDLQET 2251 SSVTAGVTLA WVLFMNFPDN IVPLLTPLMK TFSKLCKDHL SISQPKDAMA 2301 LEEARITTKL LEKVLYILSL KVSLLGDSRR PFLSTVALLI DHSMDQNFLR 2351 KIVNMSRSWI FNTEIFPTVK EKAAILTKML AFEIRGEPSL SKLFYEIVLK 2401 LFDQEHFNNT EITVRMEQPF LVGTRVEDIG IRKRFMTILD NSLERDIKER 2451 LYYVIRDQNW EFIADYPWLN QALQLLYGSF NREKELSLKN IYCLSPPSIL 2501 QEYLPENAEM VTEVNDLELS NFVKGHIASM QGLCRIISSD FIDSLIEIFY 2551 QDPKAIHRAW VTLFPQVYKS IPKNEKYGFV RSIITLLSKP YHTRQISSRT 2601 NVINMLLDSI SKIESLELPP HLVKYLAISY NAWYQSINIL ESIQSNTSID 2651 NTKIIEANED ALLELYVNLQ EEDMFYGLWR RRAKYTETNI GLSYEQIGLW 2701 DKAQQLYEVA QVKARSGALP YSQSEYALWE DNWIQCAEKL QHWDVLTELA 2751 KHEGFTDLLL ECGWRVADWN SDRDALEQSV KSVMDVPTPR RQMFKTFLAL 2801 QNFAESRKGD QEVRKLCDEG IQLSLIKWVS LPIRYTPAHK WLLHGFQQYM 2851 EFLEATQIYA NLHTTTVQNL DSKAQEIKRI LQAWRDRLPN TWDDVNMWND 2901 LVTWRQHAFQ VINNAYLPLI PALQQSNSNS NINTHAYRGY HEIAWVINRF 2951 AHVARKHNMP DVCISQLARI YTLPNIEIQE AFLKLREQAK CHYQNMNELT 3001 TGLDVISNTN LVYFGTVQKA EFFTLKGMFL SKLRAYEEAN QAFATAVQID 3051 LNLAKAWAQW GFFNDRRLSE EPNNISFASN AISCYLQAAG LYKNSKIREL 3101 LCRILWLISI DDASGMLTNA FDSFRGEIPV WYWITFIPQL LTSLSHKEAN 3151 MVRHILIRIA KSYPQALHFQ LRTTKEDFAV IQRQTMAVMG DKPDTNDRNG 3201 RRQPWEYLQE LNNILKTAYP LLALSLESLV AQINDRFKST TDEDLFRLIN 3251 VLLIDGTLNY NRLPFPRKNP KLPENTEKNL VKFSTTLLAP YIRPKFNADF 3301 IDNKPDYETY IKRLRYWRRR LENKLDRASK KENLEVLCPH LSNFHHQKFE 3351 DIEIPGQYLL NKDNNVHFIK IARFLPTVDF VRGTHSSYRR LMIRGHDGSV 3401 HSFAVQYPAV RHSRREERMF QLYRLFNKSL SKNVETRRRS IQFNLPIAIP 3451 LSPQVRIMND SVSFTTLHEI HNEFCKKKGF DPDDIQDFMA DKLNAAHDDA 3501 LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED FWLFRKQFAS 3551 QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL 3601 KNHDLSLPPD SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR 3651 ALIEPDNELN TYLALFIRDE IISWFSNLHR PIIENPQLRE MVQTNVDLII 3701 RKVAQLGHLN STPTVTTQFI LDCIGSAVSP RNLARTDVNF MPWF*

Amino Acid Sequence (or in FASTA format)

       1  MSLTEQIEQF ASRFRDDDAT LQSRYSTLSE LYDIMELLNS PEDYHFFLQA
      51  VIPLLLNQLK EVPISYDAHS PEQKLRNSML DIFNRCLMNQ TFQPYAMEVL
     101  EFLLSVLPKE NEENGILCMK VLTTLFKSFK SILQDKLDSF IRIIIQIYKN
     151  TPNLINQTFY EAGKAEQGDL DSPKEPQADE LLDEFSKNDE EKDFPSKQSS
     201  TEPRFENSTS SNGLRSSMFS FKILSECPIT MVTLYSSYKQ LTSTSLPEFT
     251  PLIMNLLNIQ IKQQQEAREQ AESRGEHFTS ISTEIINRPA YCDFILAQIK
     301  ATSFLAYVFI RGYAPEFLQD YVNFVPDLII RLLQDCPSEL SSARKELLHA
     351  TRHILSTNYK KLFLPKLDYL FDERILIGNG FTMHETLRPL AYSTVADFIH
     401  NIRSELQLSE IEKTIKIYTG YLLDESLALT VQIMSAKLLL NLVERILKLG
     451  KENPQEAPRA KKLLMIIIDS YMNRFKTLNR QYDTIMKYYG RYETHKKEKA
     501  EKLKNSIQDN DKESEEFMRK VLEPSDDDHL MPQPKKEDIN DSPDVEMTES
     551  DKVVKNDVEM FDIKNYAPIL LLPTPTNDPI KDAFYLYRTL MSFLKTIIHD
     601  LKVFNPPPNE YTVANPKLWA SVSRVFSYEE VIVFKDLFHE CIIGLKFFKD
     651  HNEKLSPETT KKHFDISMPS LPVSATKDAR ELMDYLAFMF MQMDNATFNE
     701  IIEQELPFVY ERMLEDSGLL HVAQSFLTSE ITSPNFAGIL LRFLKGKLKD
     751  LGNVDFNTSN VLIRLFKLSF MSVNLFPNIN EVVLLPHLND LILNSLKYST
     801  TAEEPLVYFY LIRTLFRSIG GGRFENLYRS IKPILQVLLQ SLNQMILTAR
     851  LPHERELYVE LCITVPVRLS VLAPYLPFLM KPLVFALQQY PDLVSQGLRT
     901  LELCIDNLTA EYFDPIIEPV IDDVSKALFN LLQPQPFNHA ISHNVVRILG
     951  KLGGRNRQFL KPPTDLTEKT ELDIDAIADF KINGMPEDVP LSVTPGIQSA
    1001  LNILQSYKSD IHYRKSAYKY LTCVLLLMTK SSAEFPTNYT ELLKTAVNSI
    1051  KLERIGIEKN FDLEPTVNKR DYSNQENLFL RLLESVFYAT SIKELKDDAM
    1101  DLLNNLLDHF CLLQVNTTLL NKRNYNGTFN IDLKNPNFML DSSLILDAIP
    1151  FALSYYIPEV REVGVLAYKR IYEKSCLIYG EELALSHSFI PELAKQFIHL
    1201  CYDETYYNKR GGVLGIKVLI DNVKSSSVFL KKYQYNLANG LLFVLKDTQS
    1251  EAPSAITDSA EKLLIDLLSI TFADVKEEDL GNKVLENTLT DIVCELSNAN
    1301  PKVRNACQKS LHTISNLTGI PIVKLMDHSK QFLLSPIFAK PLRALPFTMQ
    1351  IGNVDAITFC LSLPNTFLTF NEELFRLLQE SIVLADAEDE SLSTNIQKTT
    1401  EYSTSEQLVQ LRIACIKLLA IALKNEEFAT AQQGNIRIRI LAVFFKTMLK
    1451  TSPEIINTTY EALKGSLAEN SKLPKELLQN GLKPLLMNLS DHQKLTVPGL
    1501  DALSKLLELL IAYFKVEIGR KLLDHLTAWC RVEVLDTLFG QDLAEQMPTK
    1551  IIVSIINIFH LLPPQADMFL NDLLLKVMLL ERKLRLQLDS PFRTPLARYL
    1601  NRFHNPVTEY FKKNMTLRQL VLFMCNIVQR PEAKELAEDF EKELDNFYDF
    1651  YISNIPKNQV RVVSFFTNMV DLFNTMVITN GDEWLKKKGN MILKLKDMLN
    1701  LTLKTIKENS FYIDHLQLNQ SIAKFQALYL RFTELSERDQ NPLLLDFIDF
    1751  SFSNGIKASY SLKKFIFHNI IASSNKEKQN NFINDATLFV LSDKCLDARI
    1801  FVLKNVINST LIYEVATSGS LKSYLVEDKK PKWLELLHNK IWKNSNAILA
    1851  YDVLDHHDLF RFELLQLSAI FIKADPEIIA EIKKDIIKFC WNFIKLEDTL
    1901  IKQSAYLVTS YFISKFDFPI KVVTQVFVAL LRSSHVEARY LVKQSLDVLT
    1951  PVLHERMNAA GTPDTWINWV KRVMVENSSS QNNILYQFLI SHPDLFFNSR
    2001  DLFISNIIHH MNKITFMSNS NSDSHTLAID LASLILYWEN KTLEITNVNN
    2051  TKTDSDGDVV MSDSKSDINP VEADTTAIIV DANNNSPISL HLREACTAFL
    2101  IRYVCASNHR AIETELGLRA INILSELISD KHWTNVNVKL VYFEKFLIFQ
    2151  DLDSENILYY CMNALDVLYV FFKNKTKEWI MENLPTIQNL LEKCIKSDHH
    2201  DVQEALQKVL QVIMKAIKAQ GVSVIIEEES PGKTFIQMLT SVITQDLQET
    2251  SSVTAGVTLA WVLFMNFPDN IVPLLTPLMK TFSKLCKDHL SISQPKDAMA
    2301  LEEARITTKL LEKVLYILSL KVSLLGDSRR PFLSTVALLI DHSMDQNFLR
    2351  KIVNMSRSWI FNTEIFPTVK EKAAILTKML AFEIRGEPSL SKLFYEIVLK
    2401  LFDQEHFNNT EITVRMEQPF LVGTRVEDIG IRKRFMTILD NSLERDIKER
    2451  LYYVIRDQNW EFIADYPWLN QALQLLYGSF NREKELSLKN IYCLSPPSIL
    2501  QEYLPENAEM VTEVNDLELS NFVKGHIASM QGLCRIISSD FIDSLIEIFY
    2551  QDPKAIHRAW VTLFPQVYKS IPKNEKYGFV RSIITLLSKP YHTRQISSRT
    2601  NVINMLLDSI SKIESLELPP HLVKYLAISY NAWYQSINIL ESIQSNTSID
    2651  NTKIIEANED ALLELYVNLQ EEDMFYGLWR RRAKYTETNI GLSYEQIGLW
    2701  DKAQQLYEVA QVKARSGALP YSQSEYALWE DNWIQCAEKL QHWDVLTELA
    2751  KHEGFTDLLL ECGWRVADWN SDRDALEQSV KSVMDVPTPR RQMFKTFLAL
    2801  QNFAESRKGD QEVRKLCDEG IQLSLIKWVS LPIRYTPAHK WLLHGFQQYM
    2851  EFLEATQIYA NLHTTTVQNL DSKAQEIKRI LQAWRDRLPN TWDDVNMWND
    2901  LVTWRQHAFQ VINNAYLPLI PALQQSNSNS NINTHAYRGY HEIAWVINRF
    2951  AHVARKHNMP DVCISQLARI YTLPNIEIQE AFLKLREQAK CHYQNMNELT
    3001  TGLDVISNTN LVYFGTVQKA EFFTLKGMFL SKLRAYEEAN QAFATAVQID
    3051  LNLAKAWAQW GFFNDRRLSE EPNNISFASN AISCYLQAAG LYKNSKIREL
    3101  LCRILWLISI DDASGMLTNA FDSFRGEIPV WYWITFIPQL LTSLSHKEAN
    3151  MVRHILIRIA KSYPQALHFQ LRTTKEDFAV IQRQTMAVMG DKPDTNDRNG
    3201  RRQPWEYLQE LNNILKTAYP LLALSLESLV AQINDRFKST TDEDLFRLIN
    3251  VLLIDGTLNY NRLPFPRKNP KLPENTEKNL VKFSTTLLAP YIRPKFNADF
    3301  IDNKPDYETY IKRLRYWRRR LENKLDRASK KENLEVLCPH LSNFHHQKFE
    3351  DIEIPGQYLL NKDNNVHFIK IARFLPTVDF VRGTHSSYRR LMIRGHDGSV
    3401  HSFAVQYPAV RHSRREERMF QLYRLFNKSL SKNVETRRRS IQFNLPIAIP
    3451  LSPQVRIMND SVSFTTLHEI HNEFCKKKGF DPDDIQDFMA DKLNAAHDDA
    3501  LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED FWLFRKQFAS
    3551  QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL
    3601  KNHDLSLPPD SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR
    3651  ALIEPDNELN TYLALFIRDE IISWFSNLHR PIIENPQLRE MVQTNVDLII
    3701  RKVAQLGHLN STPTVTTQFI LDCIGSAVSP RNLARTDVNF MPWF*

external links for Tra1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tra1p

1)	Grant PA, et al. (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7
2)	Saleh A, et al. (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65
3)	Brown CE, et al. (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7
4)	Bhaumik SR, et al. (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43