SFB3/YHR098C Protein Information Help

Standard Name Sfb3p 1
Systematic Name Yhr098cp
Alias Lst1p 2
ORF Classification Verified
Description Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p (2, 3, 4, 5)
Name Description Sed Five Binding 1
Experimental Data
Molecules/cell 12200 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 929
Molecular Weight (Da) 103,949
Isoelectric Point (pI) 6.24

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sfb3p (InterPro)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001358AD | P38810
MIPS: YHR098C
NCBI: 3355839 | 487942 | 6321890 | 731688 | NP_011966.1
GenBank/EMBL/DDBJ: DAA06792.1 | AJ009784 | U00060
Amino Acid Sequence (or in FASTA format)
 
       1  MSQQNILAAS VSALSLDEST VHTGGASSKK SRRPHRAYHN FSSGTVPTLG
      51  NSPYTTPQLN QQDGFQQPQA FTPKQFGGFN NGSGSVMSTP VMVSQERFGA
     101  SEASSPYGQS MLDMTAPQPT SHIVPTQRFE DQAQYLQRSF ETCRDSVPPL
     151  PTTQFYCVDQ GSCDPHLMSL SMYNIPESEH LRAATKLPLG LTIQPFSTLT
     201  PNDAEVPTIP LPMDGTPLRC RRCRAYANPK FQFTYDSSVI CNICRVKMQV
     251  PGEHFAPMGP NGQRSDLNEK SELLHGTVDF LVPSIYNAIQ EKELLPLHYV
     301  FLIDVSLLAN ENGSSLAMVE GVRSCIEYIS DFQPNCEVAI IVYDNKLRFF
     351  NLRPDLDNAQ EYIVSELDDV FLPFYNGLFV KPGNSMKIIN DTLIKISGYI
     401  STDKYSHVPQ VCYGSALQAA KLALDTVTGG QGGKIICSLN SLPTIGNGNL
     451  SLKRDNAHIA HVKCDNGFYK KLASDFLKSY ISLDLYVTNA GFIDMATVGH
     501  PVEMTSGILK YYPHFQQETD AFTLVNDMVT NVSNIVGYQA LLKVRCSTGL
     551  SVEQYYCDSS DNTDHDPIIP VLTRDTTLDV LLKYDSKIKT GTDVHFQTAL
     601  LYTDIDGVRK VRSINTSGAV SNNIREIFKF INQNPVMRIM IKDVIKTLGD
     651  CDFVKIRRLI DDKMVEILTQ YRGLVSSNSS TQLILPDSIK TLPAYMLAFE
     701  KSELMKPNAQ STRGNERIYD LLKYDSLNSA QLCYKLYPQI VPFHVLLEET
     751  DLTFYDANDK LLQINSSSIN NLSVRASHSN FINGGCYLIF QGDTIYLWFN
     801  ENTNRMLLQD LLSVDESLPV SQISLFSGTL PETGTSINQK ASNVIKNWQQ
     851  VVNKSSLPLV LLRPNVDQYY SNVMSQLLCE DKTVNRIESY DNYLVIMHKK
     901  IQEKLQKDDF IKVSTAATHE NIHQKFVQF*

external links for Sfb3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sfb3p
1) Peng R, et al.  (2000) Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members. J Biol Chem 275(15):11521-8
2) Roberg KJ, et al.  (1999) LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum. J Cell Biol 145(4):659-72
3) Shimoni Y, et al.  (2000) Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae. J Cell Biol 151(5):973-84
4) Miller E, et al.  (2002) Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J 21(22):6105-13
5) Miller EA, et al.  (2003) Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114(4):497-509
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41