HXT5/YHR096C Protein Information

Standard Name	Hxt5p
Systematic Name	Yhr096cp
ORF Classification	Verified
Description	Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	HeXose Transporter

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	592
Molecular Weight (Da)	66,251
Isoelectric Point (pI)	7.51

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hxt5p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 32 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012CFBA \| P38695 MIPS: YHR096C NCBI: 473149 \| 487940 \| 6321888 \| 729781 \| NP_011964.1 GenBank/EMBL/DDBJ: DAA06790.1 \| U00060 \| X77961
External Classifications	TC: 2.A.1.1 [The Sugar Porter (SP) Family]

Amino Acid Sequence (or in FASTA format)
1 MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV 51 SSYISHEGPP KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF 101 GWDTGTISGF VRQTDFIRRF GSTRANGTTY LSDVRTGLMV SIFNIGCAIG 151 GIVLSKLGDM YGRKIGLMTV VVIYSIGIII QIASIDKWYQ YFIGRIISGL 201 GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG YCTNFGTKNY 251 SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA 301 NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM 351 MIQSLQQLTG DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY 401 TVDRFGRRNC LLWGCVGMIC CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM 451 IVFACFYIFC FATTWAPVAY VLISESYPLR VRGKAMSIAS ACNWIWGFLI 501 SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL TLEEVNEMYE 551 ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK*

Amino Acid Sequence (or in FASTA format)

       1  MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV
      51  SSYISHEGPP KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF
     101  GWDTGTISGF VRQTDFIRRF GSTRANGTTY LSDVRTGLMV SIFNIGCAIG
     151  GIVLSKLGDM YGRKIGLMTV VVIYSIGIII QIASIDKWYQ YFIGRIISGL
     201  GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG YCTNFGTKNY
     251  SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA
     301  NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM
     351  MIQSLQQLTG DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY
     401  TVDRFGRRNC LLWGCVGMIC CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM
     451  IVFACFYIFC FATTWAPVAY VLISESYPLR VRGKAMSIAS ACNWIWGFLI
     501  SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL TLEEVNEMYE
     551  ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK*

external links for Hxt5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Hxt5p

1)	Diderich JA, et al. (2001) Functional analysis of the hexose transporter homologue HXT5 in Saccharomyces cerevisiae. Yeast 18(16):1515-24
2)	Verwaal R, et al. (2002) HXT5 expression is determined by growth rates in Saccharomyces cerevisiae. Yeast 19(12):1029-38
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Greatrix BW and van Vuuren HJ (2006) Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress. Curr Genet 49(4):205-17