MSR1/YHR091C Protein Information

Standard Name	Msr1p 1
Systematic Name	Yhr091cp
ORF Classification	Verified
Description	Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication (1, 2, 3)
Name Description	Mitochondrial tRNA Synthetase aRginine 1
Gene Product	mitochondrial arginyl-tRNA synthetase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	643
Molecular Weight (Da)	73,693
Isoelectric Point (pI)	10.19

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Msr1p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168345 \| P38714 MIPS: YHR091C NCBI: 1174539 \| 308153546 \| 487937 \| 6321883 \| 633022 \| NP_011959.1 GenBank/EMBL/DDBJ: DAA06787.1 \| L39019 \| U00060
External Classifications	EC: 6.1.1.19 [Arginine--tRNA ligase]

Amino Acid Sequence (or in FASTA format)
1 MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY 51 SSKTLNTKYT DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN 101 SMDRGDLLLP LPKIKVADPV AVANRWAIEL STHGCIGKVC AKGPFLQFFL 151 DQRYLIQSTV PNILLQKGKY GQKKSRHQKK VVVEFSSPNI AKPFHAGHLR 201 STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK RYGDEKTLQK 251 QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK 301 IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL 351 VKEIDGALVI DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF 401 DKMVYVISSQ QDLYMSQFFM ILKKMNFEWA KDLQHINFGM VQGMSTRKGN 451 VVFLDTILDE ARDKALQIME NNKMKISQVD NPQRVADLIG VSAIIIQDMK 501 SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS DFTTDMLIHA 551 DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC 601 YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM*

Amino Acid Sequence (or in FASTA format)

       1  MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY
      51  SSKTLNTKYT DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN
     101  SMDRGDLLLP LPKIKVADPV AVANRWAIEL STHGCIGKVC AKGPFLQFFL
     151  DQRYLIQSTV PNILLQKGKY GQKKSRHQKK VVVEFSSPNI AKPFHAGHLR
     201  STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK RYGDEKTLQK
     251  QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK
     301  IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL
     351  VKEIDGALVI DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF
     401  DKMVYVISSQ QDLYMSQFFM ILKKMNFEWA KDLQHINFGM VQGMSTRKGN
     451  VVFLDTILDE ARDKALQIME NNKMKISQVD NPQRVADLIG VSAIIIQDMK
     501  SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS DFTTDMLIHA
     551  DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC
     601  YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM*

external links for Msr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Msr1p

1)	Tzagoloff A and Shtanko A (1995) Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Eur J Biochem 230(2):582-6
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Cassandrini D, et al. (2013) Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients. J Inherit Metab Dis 36(1):43-53