YNG2/YHR090C Protein Information Help

Standard Name Yng2p
Systematic Name Yhr090cp
Alias Nbn1p , Eaf4p 1
ORF Classification Verified
Description Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5 (2, 3, 4, 5, 6)
Name Description Yeast homolog of mammalian Ing1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 282
Molecular Weight (Da) 32,086
Isoelectric Point (pI) 7.97

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Yng2p (InterPro)
Physical Interactions There are 83 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B2B7 | P38806
MIPS: YHR090C
NCBI: 487936 | 6321882 | 731685 | NP_011958.1 | NM_001179220.1
GenBank/EMBL/DDBJ: AAB68930.1 | DAA06786.1 | U00060
Amino Acid Sequence (or in FASTA format)
       1  MDPSLVLEQT IQDVSNLPSE FRYLLEEIGS NDLKLIEEKK KYEQKESQIH
      51  KFIRQQGSIP KHPQEDGLDK EIKESLLKCQ SLQREKCVLA NTALFLIARH
     101  LNKLEKNIAL LEEDGVLAPV EEDGDMDSAA EASRESSVVS NSSVKKRRAA
     151  SSSGSVPPTL KKKKTSRTSK LQNEIDVSSR EKSVTPVSPS IEKKIARTKE
     201  FKNSRNGKGQ NGSPENEEED KTLYCFCQRV SFGEMVACDG PNCKYEWFHY
     251  DCVNLKEPPK GTWYCPECKI EMEKNKLKRK RN*                  

external links for Yng2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Yng2p
1) Nourani A, et al.  (2001) Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21(22):7629-40
2) Loewith R, et al.  (2000) Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol 20(11):3807-16
3) Nourani A, et al.  (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5
4) Gordon PM, et al.  (2008) Interspecies data mining to predict novel ING-protein interactions in human. BMC Genomics 9:426
5) Chittuluru JR, et al.  (2011) Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes.LID - 10.1038/nsmb.2128 [doi] Nat Struct Mol Biol ()
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30