STE12/YHR084W Protein Information

Standard Name	Ste12p
Systematic Name	Yhr084wp
ORF Classification	Verified
Description	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth (1, 2)
Name Description	STErile

Experimental Data
Molecules/cell	1920 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	688
Molecular Weight (Da)	77,866
Isoelectric Point (pI)	5.44

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ste12p (InterPro)
Physical Interactions	There are 84 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013605C \| P13574 MIPS: YHR084W NCBI: 134937 \| 172741 \| 4556 \| 500827 \| 6321876 \| NP_011952.1 GenBank/EMBL/DDBJ: DAA06779.1 \| M24502 \| U10556 \| X16112

Amino Acid Sequence (or in FASTA format)
1 MKVQITNSRT EEILKVQANN ENDEVSKATP GEVEESLRLI GDLKFFLATA 51 PVNWQENQII RRYYLNSGQG FVSCVFWNNL YYITGTDIVK CCLYRMQKFG 101 REVVQKKKFE EGIFSDLRNL KCGIDATLEQ PKSEFLSFLF RNMCLKTQKK 151 QKVFFWFSVA HDKLFADALE RDLKRESLNQ PSTTKPVNEP ALSFSYDSSS 201 DKPLYDQLLQ HLDSRRPSST TKSDNSPPKL ESENFKDNEL VTVTNQPLLG 251 VGLMDDDAPE SPSQINDFIP QKLIIEPNTL ELNGLTEETP HDLPKNTAKG 301 RDEEDFPLDY FPVSVEYPTE ENAFDPFPPQ AFTPAAPSMP ISYDNVNERD 351 SMPVNSLLNR YPYQLSVAPT FPVPPSSSRQ HFMTNRDFYS SNNNKEKLVS 401 PSDPTSYMKY DEPVMDFDES RPNENCTNAK SHNSGQQTKQ HQLYSNNFQQ 451 SYPNGMVPGY YPKMPYNPMG GDPLLDQAFY GADDFFFPPE GCDNNMLYPQ 501 TATSWNVLPP QAMQPAPTYV GRPYTPNYRS TPGSAMFPYM QSSNSMQWNT 551 AVSPYSSRAP STTAKNYPPS TFYSQNINQY PRRRTVGMKS SQGNVPTGNK 601 QSVGKSAKIS KPLHIKTSAY QKQYKINLET KARPSAGDED SAHPDKNKEI 651 SMPTPDSNTL VVQSEEGGAH SLEVDTNRRS DKNLPDAT*

Amino Acid Sequence (or in FASTA format)

       1  MKVQITNSRT EEILKVQANN ENDEVSKATP GEVEESLRLI GDLKFFLATA
      51  PVNWQENQII RRYYLNSGQG FVSCVFWNNL YYITGTDIVK CCLYRMQKFG
     101  REVVQKKKFE EGIFSDLRNL KCGIDATLEQ PKSEFLSFLF RNMCLKTQKK
     151  QKVFFWFSVA HDKLFADALE RDLKRESLNQ PSTTKPVNEP ALSFSYDSSS
     201  DKPLYDQLLQ HLDSRRPSST TKSDNSPPKL ESENFKDNEL VTVTNQPLLG
     251  VGLMDDDAPE SPSQINDFIP QKLIIEPNTL ELNGLTEETP HDLPKNTAKG
     301  RDEEDFPLDY FPVSVEYPTE ENAFDPFPPQ AFTPAAPSMP ISYDNVNERD
     351  SMPVNSLLNR YPYQLSVAPT FPVPPSSSRQ HFMTNRDFYS SNNNKEKLVS
     401  PSDPTSYMKY DEPVMDFDES RPNENCTNAK SHNSGQQTKQ HQLYSNNFQQ
     451  SYPNGMVPGY YPKMPYNPMG GDPLLDQAFY GADDFFFPPE GCDNNMLYPQ
     501  TATSWNVLPP QAMQPAPTYV GRPYTPNYRS TPGSAMFPYM QSSNSMQWNT
     551  AVSPYSSRAP STTAKNYPPS TFYSQNINQY PRRRTVGMKS SQGNVPTGNK
     601  QSVGKSAKIS KPLHIKTSAY QKQYKINLET KARPSAGDED SAHPDKNKEI
     651  SMPTPDSNTL VVQSEEGGAH SLEVDTNRRS DKNLPDAT*

external links for Ste12p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ste12p

1)	Bardwell L, et al. (1998) Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev 12(18):2887-98
2)	Roberts RL and Fink GR (1994) Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev 8(24):2974-85
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41