PTC7/YHR076W Protein Information

Standard Name	Ptc7p 1
Systematic Name	Yhr076wp
ORF Classification	Verified
Description	Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope (1, 2, 3, 4, 5)
Name Description	Phosphatase type Two C 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	343
Molecular Weight (Da)	37,782
Isoelectric Point (pI)	6.54

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ptc7p (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000153C035 \| P38797 MIPS: YHR076W NCBI: 115361651 \| 124263204 \| 150421629 \| 154199605 \| 500831 \| 731677 \| NP_011943.2 GenBank/EMBL/DDBJ: DAA06770.1 \| DQ881450 \| EF123135 \| U10556
External Classifications	EC: 3.1.3.16 [Phosphoprotein phosphatase]

Amino Acid Sequence (or in FASTA format)
1 MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY 51 SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV 101 HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT 151 PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR 201 DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY 251 SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD 301 NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD*

Amino Acid Sequence (or in FASTA format)

       1  MFANVGFRTL RVSRGPLYGS CSQIISFSKR TFYSSAKSGY QSNNSHGDAY
      51  SSGSQSGPFT YKTAVAFQPK DRDDLIYQKL KDSIRSPTGE DNYFVTSNNV
     101  HDIFAGVADG VGGWAEHGYD SSAISRELCK KMDEISTALA ENSSKETLLT
     151  PKKIIGAAYA KIRDEKVVKV GGTTAIVAHF PSNGKLEVAN LGDSWCGVFR
     201  DSKLVFQTKF QTVGFNAPYQ LSIIPEEMLK EAERRGSKYI LNTPRDADEY
     251  SFQLKKKDII ILATDGVTDN IATDDIELFL KDNAARTNDE LQLLSQKFVD
     301  NVVSLSKDPN YPSVFAQEIS KLTGKNYSGG KEDDITVVVV RVD*

external links for Ptc7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ptc7p

1)	Jiang L, et al. (2002) The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast. FEBS Lett 527(1-3):323-5
2)	Ramos CW, et al. (2000) Molecular analysis of the Saccharomyces cerevisiae YHR076w gene. IUBMB Life 50(6):371-7
3)	Runner VM and Brewster JL (2003) A genetic screen for yeast genes induced by sustained osmotic stress. Yeast 20(10):913-20
4)	Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
5)	Juneau K, et al. (2009) Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localization. Genetics 183(1):185-94