QNS1/YHR074W Protein Information Help

Standard Name Qns1p 1
Systematic Name Yhr074wp
ORF Classification Verified
Description Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide (1, 2)
Name Description glutamine (Q) dependent Nad+ Synthetase 1
Experimental Data
Molecules/cell 172 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 714
Molecular Weight (Da) 80,685
Isoelectric Point (pI) 6.5

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Qns1p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012FCEB | P38795
MIPS: YHR074W
NCBI: 500832 | 6321865 | 731675 | NP_011941.1
GenBank/EMBL/DDBJ: DAA06768.1 | U10556
External Classifications EC: 6.3.5.1 [NAD(+) synthase (glutamine-hydrolyzing)]
Amino Acid Sequence (or in FASTA format)
 
       1  MSHLITLATC NLNQWALDFE GNRDRILQSI KIAKERGARL RVGPELEITG
      51  YGCLDHFLEN DVCLHSWEMY AQIIKNKETH GLILDIGMPV LHKNVRYNCR
     101  LLSLDGEILF IRPKIWLAND GNYREMRFFT PWMKPGVVED FILPPEIQKV
     151  TGQRLVPFGD AVINSLDTCI GTETCEELFT PQSPHIAMSL DGVEIMTNSS
     201  GSHHELRKLN KRLDLILNAT KRCGGVYLYA NQRGCDGDRL YYDGCALIAI
     251  NGTIVAQGSQ FSLDDVEVVT ATVDLEEVRS YRAAVMSRGL QASLAEIKFK
     301  RIDIPVELAL MTSRFDPTVC PTKVREPFYH SPEEEIALGP ACWMWDYLRR
     351  CNGTGFFLPL SGGIDSCATA MIVHSMCRLV TDAAQNGNEQ VIKDVRKITR
     401  SGDDWIPDSP QDLASKIFHS CFMGTENSSK ETRNRAKDLS NAIGSYHVDL
     451  KMDSLVSSVV SLFEVATGKK PIYKIFGGSQ IENLALQNIQ ARLRMVLSYL
     501  FAQLLPWVRG IPNSGGLLVL GSANVDECLR GYLTKYDCSS ADINPIGGIS
     551  KTDLKRFIAY ASKQYNMPIL NDFLNATPTA ELEPMTKDYV QSDEIDMGMT
     601  YEELGVFGYL RKVEKCGPYS MFLKLLHQWS PKLTPRQISE KVKRFFFFYA
     651  INRHKQTVLT PSYHAEQYSP EDNRFDLRPF LINPRFPWAS RKIDEVVEQC
     701  EAHKGSTLDI MSID*

external links for Qns1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Qns1p
1) Bieganowski P, et al.  (2003) Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. J Biol Chem 278(35):33049-55
2) Suda Y, et al.  (2003) Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals. Yeast 20(11):995-1005
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41