ERG7/YHR072W Protein Information Help

Standard Name Erg7p 1, 2
Systematic Name Yhr072wp
ORF Classification Verified
Description Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis (3, 4, 5, 6, 7)
Name Description ERGosterol biosynthesis 1
Experimental Data
Molecules/cell 2190 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 731
Molecular Weight (Da) 83,460
Isoelectric Point (pI) 6.59

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Erg7p (InterPro)
Physical Interactions There are 42 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000168A14 | P38604
MIPS: YHR072W
NCBI: 1169548 | 1549343 | 330443583 | 341941150 | 465105 | 500834 | 51013537 | 733000 | NP_011939.2 | NM_001179202.2
GenBank/EMBL/DDBJ: DAA06765.2 | AY693043 | U04841 | U10556 | U23488 | U60996
External Classifications EC: 5.4.99.7 [Lanosterol synthase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTEFYSDTIG LPKTDPRLWR LRTDELGRES WEYLTPQQAA NDPPSTFTQW
      51  LLQDPKFPQP HPERNKHSPD FSAFDACHNG ASFFKLLQEP DSGIFPCQYK
     101  GPMFMTIGYV AVNYIAGIEI PEHERIELIR YIVNTAHPVD GGWGLHSVDK
     151  STVFGTVLNY VILRLLGLPK DHPVCAKARS TLLRLGGAIG SPHWGKIWLS
     201  ALNLYKWEGV NPAPPETWLL PYSLPMHPGR WWVHTRGVYI PVSYLSLVKF
     251  SCPMTPLLEE LRNEIYTKPF DKINFSKNRN TVCGVDLYYP HSTTLNIANS
     301  LVVFYEKYLR NRFIYSLSKK KVYDLIKTEL QNTDSLCIAP VNQAFCALVT
     351  LIEEGVDSEA FQRLQYRFKD ALFHGPQGMT IMGTNGVQTW DCAFAIQYFF
     401  VAGLAERPEF YNTIVSAYKF LCHAQFDTEC VPGSYRDKRK GAWGFSTKTQ
     451  GYTVADCTAE AIKAIIMVKN SPVFSEVHHM ISSERLFEGI DVLLNLQNIG
     501  SFEYGSFATY EKIKAPLAME TLNPAEVFGN IMVEYPYVEC TDSSVLGLTY
     551  FHKYFDYRKE EIRTRIRIAI EFIKKSQLPD GSWYGSWGIC FTYAGMFALE
     601  ALHTVGETYE NSSTVRKGCD FLVSKQMKDG GWGESMKSSE LHSYVDSEKS
     651  LVVQTAWALI ALLFAEYPNK EVIDRGIDLL KNRQEESGEW KFESVEGVFN
     701  HSCAIEYPSY RFLFPIKALG MYSRAYETHT L*

external links for Erg7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Erg7p
1) Karst F and Lacroute F  (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol Gen Genet 154(3):269-77
2) Griffin, J.H. et al.  (1996) Mutations in the Oxidosqualene-Lanosterol Cyclase gene of Saccharomyces cerevisiae. Unpublished
3) Lees ND, et al.  (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6
4) Parks LW, et al.  (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30
5) Shi Z, et al.  (1994) Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(15):7370-4
6) Corey EJ, et al.  (1994) Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci U S A 91(6):2211-5
7) Paltauf F, et al.  (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41