PAN5/YHR063C Protein Information

Standard Name	Pan5p
Systematic Name	Yhr063cp
ORF Classification	Verified
Description	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE (1)
Name Description	PANtothenate biosynthesis 1

Experimental Data
Molecules/cell	2600 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	379
Molecular Weight (Da)	42,821
Isoelectric Point (pI)	6.61

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pan5p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001312E0 \| P38787 MIPS: YHR063C NCBI: 487959 \| 6321854 \| 731665 \| NP_011930.1 GenBank/EMBL/DDBJ: DAA06756.1 \| U00061
External Classifications	EC: 1.1.1.169 [2-dehydropantoate 2-reductase]

Amino Acid Sequence (or in FASTA format)
1 MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN 51 GNNISIRKLY LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA 101 LAPYLPYINK NTNLILIQNG LGVLELLREE IFTDSKNRPH LFQGVISHGV 151 YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ KKSVVEDDAA NNSLVKLLTE 201 PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC VNGEMKASCG 251 PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS 301 EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC 351 KVNKTIGELA TMRLALNRSR SINGDWRKD*

Amino Acid Sequence (or in FASTA format)

       1  MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN
      51  GNNISIRKLY LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA
     101  LAPYLPYINK NTNLILIQNG LGVLELLREE IFTDSKNRPH LFQGVISHGV
     151  YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ KKSVVEDDAA NNSLVKLLTE
     201  PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC VNGEMKASCG
     251  PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS
     301  EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC
     351  KVNKTIGELA TMRLALNRSR SINGDWRKD*

external links for Pan5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pan5p

1)	White WH, et al. (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41