RPP1/YHR062C Protein Information

Standard Name	Rpp1p
Systematic Name	Yhr062cp
ORF Classification	Verified
Description	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs (1, 2, 3)
Name Description	Ribonuclease P Protein

Experimental Data
Molecules/cell	6300 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	293
Molecular Weight (Da)	32,224
Isoelectric Point (pI)	10.54

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpp1p (InterPro)
Physical Interactions	There are 52 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000134814 \| P38786 MIPS: YHR062C NCBI: 2772821 \| 487958 \| 6321853 \| 731664 \| NP_011929.1 GenBank/EMBL/DDBJ: DAA06755.1 \| U00061 \| U95757
External Classifications	EC: 3.1.26.5 [Ribonuclease P]

Amino Acid Sequence (or in FASTA format)
1 MLVDLNVPWP QNSYADKVTS QAVNNLIKTL STLHMLGYTH IAINFTVNHS 51 EKFPNDVKLL NPIDIKRRFG ELMDRTGLKL YSRITLIIDD PSKGQSLSKI 101 SQAFDIVAAL PISEKGLTLS TTNLDIDLLT FQYGSRLPTF LKHKSICSCV 151 NRGVKLEIVY GYALRDVQAR RQFVSNVRSV IRSSRSRGIV IGSGAMSPLE 201 CRNILGVTSL IKNLGLPSDR CSKAMGDLAS LVLLNGRLRN KSHKQTIVTG 251 GGSGNGDDVV NDVQGIDDVQ TIKVVKRSMD AEQLGHASKR HKP*

Amino Acid Sequence (or in FASTA format)

       1  MLVDLNVPWP QNSYADKVTS QAVNNLIKTL STLHMLGYTH IAINFTVNHS
      51  EKFPNDVKLL NPIDIKRRFG ELMDRTGLKL YSRITLIIDD PSKGQSLSKI
     101  SQAFDIVAAL PISEKGLTLS TTNLDIDLLT FQYGSRLPTF LKHKSICSCV
     151  NRGVKLEIVY GYALRDVQAR RQFVSNVRSV IRSSRSRGIV IGSGAMSPLE
     201  CRNILGVTSL IKNLGLPSDR CSKAMGDLAS LVLLNGRLRN KSHKQTIVTG
     251  GGSGNGDDVV NDVQGIDDVQ TIKVVKRSMD AEQLGHASKR HKP*

external links for Rpp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Rpp1p

1)	Stolc V and Altman S (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev 11(21):2926-37
2)	Houser-Scott F, et al. (2002) Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Proc Natl Acad Sci U S A 99(5):2684-9
3)	Marvin MC, et al. (2011) Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. RNA 17(8):1441-50
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41