CUP1-2/YHR055C Protein Information 
| Standard Name | Cup1-2p |
|---|---|
| Systematic Name | Yhr055cp |
| Alias | Cup1p |
| ORF Classification | Verified |
| Description | Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication (1, 2, 3) |
| Experimental Data | |
|---|---|
| Molecules/cell | 6680 4 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Cup1-2p (InterPro) |
| Physical Interactions | There are 5 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000004F922 | P0CX81 MIPS: YHR055C NCBI: 338818299 | 487953 | 51013605 | 6321844 | 6321846 | NP_011920.1 | NP_011922.1 | NM_001179183.1 | NM_001179185.1 GenBank/EMBL/DDBJ: DAA06746.1 | AY693077 | U00061 |
external links for Cup1-2p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| YGOB | BioPIXIE | MIPS | YeastGFP |
| YOGY | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Complexome | YeastRC Structure Prediction (Seattle) | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Cup1-2p
| 1) | Winge DR, et al. (1985) Yeast metallothionein. Sequence and metal-binding properties. J Biol Chem 260(27):14464-70 |
| 2) | Karin M, et al. (1984) Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A 81(2):337-41 |
| 3) | Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75 |
| 4) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
