CIC1/YHR052W Protein Information

Standard Name	Cic1p 1
Systematic Name	Yhr052wp
Alias	Nsa3p 2
ORF Classification	Verified
Description	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles (1, 2, 3)
Name Description	Core Interacting Component 1

Experimental Data
Molecules/cell	45900 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	376
Molecular Weight (Da)	42,529
Isoelectric Point (pI)	9.54

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cic1p (InterPro)
Physical Interactions	There are 289 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053118 \| P38779 MIPS: YHR052W NCBI: 45269559 \| 488163 \| 6321843 \| 731657 \| NP_011919.1 GenBank/EMBL/DDBJ: DAA06745.1 \| AY557834 \| U00062

Amino Acid Sequence (or in FASTA format)
1 MAKKSNSKKS TPVSTPSKEK KKVIEKKSST AIPRERVIKA VNELIKFTSK 51 PQDENNEEGN NGKKNLLEDD EEELKKDLQL IVVNNKSFTG TSKSFKLKLL 101 NVKHSFYKPW KEASATAVKD FKVLLILKDS DIKKVSEDDL FDQLDSEGIK 151 VDEIICGKDL KTVYKAYEAR NAFISQFSLI LADDSIVTSL PKLMGGKAYN 201 KVETTPISIR THANKEFSLT TLTNNIKKVY MNQLPVKLPR GTTLNVHLGN 251 LEWLRPEEFV DNVELISEQL IKAYQIRSIF IKTNRSPVLP LYYNQDVLDE 301 LEAKKDKIEE THEDDMVTID GVQVHLSTFN KGLMEIANPS ELGSIFSKQI 351 NNAKKRSSSE LEKESSESEA VKKAKS*

Amino Acid Sequence (or in FASTA format)

       1  MAKKSNSKKS TPVSTPSKEK KKVIEKKSST AIPRERVIKA VNELIKFTSK
      51  PQDENNEEGN NGKKNLLEDD EEELKKDLQL IVVNNKSFTG TSKSFKLKLL
     101  NVKHSFYKPW KEASATAVKD FKVLLILKDS DIKKVSEDDL FDQLDSEGIK
     151  VDEIICGKDL KTVYKAYEAR NAFISQFSLI LADDSIVTSL PKLMGGKAYN
     201  KVETTPISIR THANKEFSLT TLTNNIKKVY MNQLPVKLPR GTTLNVHLGN
     251  LEWLRPEEFV DNVELISEQL IKAYQIRSIF IKTNRSPVLP LYYNQDVLDE
     301  LEAKKDKIEE THEDDMVTID GVQVHLSTFN KGLMEIANPS ELGSIFSKQI
     351  NNAKKRSSSE LEKESSESEA VKKAKS*

external links for Cic1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cic1p

1)	Jager S, et al. (2001) Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. EMBO J 20(16):4423-31
2)	Harnpicharnchai P, et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41