DOG2/YHR043C Protein Information

Standard Name	Dog2p
Systematic Name	Yhr043cp
ORF Classification	Verified
Description	2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication (1, 2, 3, 4)
Name Description	DeOxyGlucose 3
Gene Product	2-deoxyglucose-6-phosphate phosphatase 3

Experimental Data
Molecules/cell	2400 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	246
Molecular Weight (Da)	27,165
Isoelectric Point (pI)	5.46

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dog2p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001296A8 \| P38773 MIPS: YHR043C NCBI: 488181 \| 6321833 \| 729360 \| NP_011909.1 GenBank/EMBL/DDBJ: DAA06735.1 \| U00062
External Classifications	EC: 3.1.3.68 [2-deoxyglucose-6-phosphatase]

Amino Acid Sequence (or in FASTA format)
1 MPQFSVDLCL FDLDGTIVST TTAAESAWKK LCRQHGVDPV ELFKHSHGAR 51 SQEMMKKFFP KLDNTDNKGV LALEKDMADN YLDTVSLIPG AENLLLSLDV 101 DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG 151 KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG 201 ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRD*

Amino Acid Sequence (or in FASTA format)

       1  MPQFSVDLCL FDLDGTIVST TTAAESAWKK LCRQHGVDPV ELFKHSHGAR
      51  SQEMMKKFFP KLDNTDNKGV LALEKDMADN YLDTVSLIPG AENLLLSLDV
     101  DTETQKKLPE RKWAIVTSGS PYLAFSWFET ILKNVGKPKV FITGFDVKNG
     151  KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV FEDAPVGIKA GKAMGAITVG
     201  ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN NPLTRD*

external links for Dog2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Dog2p

1)	Tsujimoto Y, et al. (2000) Cooperative regulation of DOG2, encoding 2-deoxyglucose-6-phosphate phosphatase, by Snf1 kinase and the high-osmolarity glycerol-mitogen-activated protein kinase cascade in stress responses of Saccharomyces cerevisiae. J Bacteriol 182(18):5121-6
2)	Norbeck J, et al. (1996) Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J Biol Chem 271(23):13875-81
3)	Randez-Gil F, et al. (1995) DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed. Yeast 11(13):1233-40
4)	Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41