RRM3/YHR031C Protein Information Help

Standard Name Rrm3p 1
Systematic Name Yhr031cp
Alias Rtt104p
ORF Classification Verified
Description DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p (2, 3)
Name Description rDNA Recombination Mutation
Experimental Data
Molecules/cell 656 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 723
Molecular Weight (Da) 81,580
Isoelectric Point (pI) 10.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rrm3p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000003ACFE | P38766
MIPS: YHR031C
NCBI: 488178 | 6321820 | 731644 | NP_011896.1
GenBank/EMBL/DDBJ: DAA06722.1 | U00062
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.-
Amino Acid Sequence (or in FASTA format)
 
       1  MFRSHASGNK KQWSKRSSNG STPAASASGS HAYRQQTLSS FFMGCGKKSA
      51  AASKNSTTII DLESGDEGNR NITAPPRPRL IRNNSSSLFS QSQGSFGDDD
     101  PDAEFKKLVD VPRLNSYKKS SRSLSMTSSL HKTASASTTQ KTYHFDEDET
     151  LREVTSVKSN SRQLSFTSTI NIEDSSMKLS TDSERPAKRS KPSMEFQGLK
     201  LTVPKKIKPL LRKTVSNMDS MNHRSASSPV VLTMEQERVV NLIVKKRTNV
     251  FYTGSAGTGK SVILQTIIRQ LSSLYGKESI AITASTGLAA VTIGGSTLHK
     301  WSGIGIGNKT IDQLVKKIQS QKDLLAAWRY TKVLIIDEIS MVDGNLLDKL
     351  EQIARRIRKN DDPFGGIQLV LTGDFFQLPP VAKKDEHNVV KFCFESEMWK
     401  RCIQKTILLT KVFRQQDNKL IDILNAIRYG ELTVDIAKTI RNLNRDIDYA
     451  DGIAPTELYA TRREVELSNV KKLQSLPGDL YEFKAVDNAP ERYQAILDSS
     501  LMVEKVVALK EDAQVMMLKN KPDVELVNGS LGKVLFFVTE SLVVKMKEIY
     551  KIVDDEVVMD MRLVSRVIGN PLLKESKEFR QDLNARPLAR LERLKILINY
     601  AVKISPHKEK FPYVRWTVGK NKYIHELMVP ERFPIDIPRE NVGLERTQIP
     651  LMLCWALSIH KAQGQTIQRL KVDLRRIFEA GQVYVALSRA VTMDTLQVLN
     701  FDPGKIRTNE RVKDFYKRLE TLK*

external links for Rrm3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rrm3p
1) Scholes DT, et al.  (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
2) Ivessa AS, et al.  (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89
3) Makovets S, et al.  (2004) Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol 24(9):4019-31
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41