RPN1/YHR027C Protein Information Help

Standard Name Rpn1p 1
Systematic Name Yhr027cp
Alias Hrd2p , Nas1p
ORF Classification Verified
Description Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions (2, 3)
Name Description Regulatory Particle Non-ATPase 1
Experimental Data
Molecules/cell 306000 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 993
Molecular Weight (Da) 109,491
Isoelectric Point (pI) 4.35

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rpn1p (InterPro)
Physical Interactions There are 657 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000134646 | P38764
MIPS: YHR027C
NCBI: 500697 | 6321816 | 731642 | NP_011892.1
GenBank/EMBL/DDBJ: DAA06718.1 | U10399
Amino Acid Sequence (or in FASTA format)
 
       1  MVDESDKKQQ TIDEQSQISP EKQTPNKKDK KKEEEEQLSE EDAKLKTDLE
      51  LLVERLKEDD SSLYEASLNA LKESIKNSTS SMTAVPKPLK FLRPTYPDLC
     101  SIYDKWTDPN LKSSLADVLS ILAMTYSENG KHDSLRYRLL SDVSDFEGWG
     151  HEYIRHLALE IGEVYNDQVE KDAEDETSSD GSKSDGSAAT SGFEFSKEDT
     201  LRLCLDIVPY FLKHNGEEDA VDLLLEIESI DKLPQFVDEN TFQRVCQYMV
     251  ACVPLLPPPE DVAFLKTAYS IYLSQNELTD AIALAVRLGE EDMIRSVFDA
     301  TSDPVMHKQL AYILAAQKTS FEYEGVQDII GNGKLSEHFL YLAKELNLTG
     351  PKVPEDIYKS HLDNSKSVFS SAGLDSAQQN LASSFVNGFL NLGYCNDKLI
     401  VDNDNWVYKT KGDGMTSAVA SIGSIYQWNL DGLQQLDKYL YVDEPEVKAG
     451  ALLGIGISAS GVHDGEVEPA LLLLQDYVTN PDTKISSAAI LGLGIAFAGS
     501  KNDEVLGLLL PIAASTDLPI ETAAMASLAL AHVFVGTCNG DITTSIMDNF
     551  LERTAIELKT DWVRFLALAL GILYMGQGEQ VDDVLETISA IEHPMTSAIE
     601  VLVGSCAYTG TGDVLLIQDL LHRLTPKNVK GEEDADEEET AEGQTNSISD
     651  FLGEQVNEPT KNEEAEIEVD EMEVDAEGEE VEVKAEITEK KNGESLEGEE
     701  IKSEEKKGKS SDKDATTDGK NDDEEEEKEA GIVDELAYAV LGIALIALGE
     751  DIGKEMSLRH FGHLMHYGNE HIRRMVPLAM GIVSVSDPQM KVFDTLTRFS
     801  HDADLEVSMN SIFAMGLCGA GTNNARLAQL LRQLASYYSR EQDALFITRL
     851  AQGLLHLGKG TMTMDVFNDA HVLNKVTLAS ILTTAVGLVS PSFMLKHHQL
     901  FYMLNAGIRP KFILALNDEG EPIKVNVRVG QAVETVGQAG RPKKITGWIT
     951  QSTPVLLNHG ERAELETDEY ISYTSHIEGV VILKKNPDYR EEE*

external links for Rpn1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rpn1p
1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Glickman MH, et al.  (1998) A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94(5):615-23
3) Elsasser S, et al.  (2002) Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol 4(9):725-30
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41