SOD2/YHR008C Protein Information

Standard Name	Sod2p 1
Systematic Name	Yhr008cp
ORF Classification	Verified
Description	Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated (2, 3, 4)
Name Description	SuperOxide Dismutase 2

Experimental Data
Molecules/cell	10900 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	233
Molecular Weight (Da)	25,774
Isoelectric Point (pI)	9.03

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sod2p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135C58 \| P00447 MIPS: YHR008C NCBI: 134681 \| 217035334 \| 295665 \| 323714460 \| 323714461 \| 323714462 \| 323714463 \| 358009559 \| 401871503 \| 401871504 \| 401871505 \| 401871506 \| 4514 \| 45269533 \| 500704 \| 6321796 \| NP_011872.1 GenBank/EMBL/DDBJ: DAA06697.1 \| AY557821 \| M24079 \| U10400 \| X02156
External Classifications	EC: 1.15.1.1 [Superoxide dismutase]

Amino Acid Sequence (or in FASTA format)
1 MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE 51 LHYTKHHQTY VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH 101 GGGFTNHCLF WENLAPESQG GGEPPTGALA KAIDEQFGSL DELIKLTNTK 151 LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ DTVTGPLVPL VAIDAWEHAY 201 YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI*

Amino Acid Sequence (or in FASTA format)

       1  MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE
      51  LHYTKHHQTY VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH
     101  GGGFTNHCLF WENLAPESQG GGEPPTGALA KAIDEQFGSL DELIKLTNTK
     151  LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ DTVTGPLVPL VAIDAWEHAY
     201  YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI*

external links for Sod2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Sod2p

1)	Gralla, E. and Kosman, D. (1992) Personal Communication, Mortimer Map Edition 11
2)	van Loon AP, et al. (1986) A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen. Proc Natl Acad Sci U S A 83(11):3820-4
3)	Saffi J, et al. (2006) Antioxidant activity of L-ascorbic acid in wild-type and superoxide dismutase deficient strains of Saccharomyces cerevisiae. Redox Rep 11(4):179-84
4)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41