STP2/YHR006W Protein Information

Standard Name	Stp2p 1
Systematic Name	Yhr006wp
ORF Classification	Verified
Description	Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication (2, 3, 4)
Name Description	protein with similarity to Stp1p 2

Experimental Data
Molecules/cell	6490 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	541
Molecular Weight (Da)	60,792
Isoelectric Point (pI)	6.27

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Stp2p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B236 \| P38704 MIPS: YHR006W NCBI: 500814 \| 51830374 \| 6321794 \| 731631 \| NP_011870.1 GenBank/EMBL/DDBJ: DAA06694.1 \| AY723821 \| U10555

Amino Acid Sequence (or in FASTA format)
1 MPILSLSSTR NSVLTRIYDY LKALVQQVIV PNVEDDKSSK STPFEKLEPA 51 KQNHPQKDCC ATEKDDLVDV SELFPKQNNK QLSLTSKSSV VPCALNLDNL 101 ETPFSIKIDN NGAVTTQLNL DEPILRGPSR GEPAKLQNDL ISSPPLEESY 151 INNDQYKALF PSNFLPITPV SSVITPASKK SIDESPLSDE VQGIADESSE 201 TLPYICHYCD ARFRIRGYLT RHIKKHAKRK AYHCPFFDNS ISQELRCHTS 251 GGFSRRDTYK THLKSRHFTY PEGVKPQDRN KSPGVCTQCG EHFSTSESWV 301 ENHIEAGSCK GLPEGYSEGI REKKKTSKMK MIKTSDGQTR FISSDESVSE 351 PALQNKNCIE ATVMQSKERP NDKIIPTKTE KNDFGIGTQW FERKQISRPT 401 QTTQSRGPTE VQNLKEWSII SPPILSPQNA SSVPQEYQSS RYTLHMDSPA 451 LSSASSALSP LSGDPITTTE TNKSYPLDSE QSLLEPDKTE EDAINQSKES 501 NMISINEMLQ KQMDFELLGE NHLKETQDYL ALYKKAYGIE F*

Amino Acid Sequence (or in FASTA format)

       1  MPILSLSSTR NSVLTRIYDY LKALVQQVIV PNVEDDKSSK STPFEKLEPA
      51  KQNHPQKDCC ATEKDDLVDV SELFPKQNNK QLSLTSKSSV VPCALNLDNL
     101  ETPFSIKIDN NGAVTTQLNL DEPILRGPSR GEPAKLQNDL ISSPPLEESY
     151  INNDQYKALF PSNFLPITPV SSVITPASKK SIDESPLSDE VQGIADESSE
     201  TLPYICHYCD ARFRIRGYLT RHIKKHAKRK AYHCPFFDNS ISQELRCHTS
     251  GGFSRRDTYK THLKSRHFTY PEGVKPQDRN KSPGVCTQCG EHFSTSESWV
     301  ENHIEAGSCK GLPEGYSEGI REKKKTSKMK MIKTSDGQTR FISSDESVSE
     351  PALQNKNCIE ATVMQSKERP NDKIIPTKTE KNDFGIGTQW FERKQISRPT
     401  QTTQSRGPTE VQNLKEWSII SPPILSPQNA SSVPQEYQSS RYTLHMDSPA
     451  LSSASSALSP LSGDPITTTE TNKSYPLDSE QSLLEPDKTE EDAINQSKES
     501  NMISINEMLQ KQMDFELLGE NHLKETQDYL ALYKKAYGIE F*

external links for Stp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Stp2p

1)	Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
2)	de Boer M, et al. (2000) Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. Nucleic Acids Res 28(4):974-81
3)	Andreasson C and Ljungdahl PO (2002) Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Genes Dev 16(24):3158-72
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41