COS8/YHL048W Protein Information Help

Standard Name Cos8p
Systematic Name Yhl048wp
ORF Classification Verified
Description Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response (1, 2)
Name Description COnserved Sequence
Experimental Data
Molecules/cell 3070 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 381
Molecular Weight (Da) 45,879
Isoelectric Point (pI) 8.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cos8p (InterPro)
Transmembrane Domains There are 3 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 50 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000127F2F | P38723
MIPS: YHL048W
NCBI: 2289877 | 6321739 | 731624 | NP_011815.1 | NM_001179128.1
GenBank/EMBL/DDBJ: DAA06640.1 | U11583
Amino Acid Sequence (or in FASTA format)
 
       1  MKENEVKDEK SVDVLSFKQL EFQKTVLPQD VFRNELTWFC YEIYKSLAFR
      51  IWMLLWLPLS VWWKLSSNWI HPLIVSLLVL FLGPFFVLVI CGLSRKRSLS
     101  KQLIQFCKEI TEDTPSSDPH DWEVVAANLN SYFYENKTWN TKYFFFNAMS
     151  CQKAFKTTLL EPFSLKKDES AKVKSFKDSV PYIEEALQVY AAGFDKEWKL
     201  FNTEKEESPF DLEDIQLPKE AYRFKLTWIL KRIFNLRCLP LFLYYFLIVY
     251  TSGNADLISR FLFPVVMFFI MTRDFQNMRM IVLSVKMEHK MQFLSTIINE
     301  QESGANGWDE IAKKMNRYLF EKKVWNNEEF FYDGLDCEWF FRRFFYRLLS
     351  LKKPMWFASL NVELWPYIKE AQSARNEKPL K*

external links for Cos8p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cos8p
1) Spode I, et al.  (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20
2) Despons L, et al.  (2006) An evolutionary scenario for one of the largest yeast gene families. Trends Genet 22(1):10-5
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41