ARN2/YHL047C Protein Information

Standard Name	Arn2p 1
Systematic Name	Yhl047cp
Alias	Taf1p 2
ORF Classification	Verified
Description	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C (2, 3)
Name Description	AFT1 ReguloN 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	620
Molecular Weight (Da)	69,566
Isoelectric Point (pI)	8.4

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arn2p (InterPro)
Transmembrane Domains	There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD48 \| P38724 MIPS: YHL047C NCBI: 2289876 \| 330443580 \| 341940242 \| 731623 \| NP_011816.2 GenBank/EMBL/DDBJ: DAA06641.2 \| U11583
External Classifications	TC: 2.A.1.16 [The Siderophore-Iron Transporter (SIT) Family]

Amino Acid Sequence (or in FASTA format)
1 MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS 51 LIIRKSELMA KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS 101 YSAHSLISTV SVIVLMISAV SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI 151 IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV LMLSDNSSLK WRLFYTLIPS 201 WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP LILCMLHMRW 251 KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL 301 VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL 351 KDRGVWAPLG IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF 401 VTAVVAPFLG LIVTRSSRLK SYIIFGGSLY FITMGLFYRY RSGQDADGGI 451 IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN MATVTALNYT VFRIGGAVAA 501 AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP WGTPVRSAMV 551 EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK 601 EDDPINDWIA KRFAKALGRS *

Amino Acid Sequence (or in FASTA format)

       1  MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS
      51  LIIRKSELMA KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS
     101  YSAHSLISTV SVIVLMISAV SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI
     151  IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV LMLSDNSSLK WRLFYTLIPS
     201  WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP LILCMLHMRW
     251  KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL
     301  VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL
     351  KDRGVWAPLG IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF
     401  VTAVVAPFLG LIVTRSSRLK SYIIFGGSLY FITMGLFYRY RSGQDADGGI
     451  IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN MATVTALNYT VFRIGGAVAA
     501  AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP WGTPVRSAMV
     551  EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK
     601  EDDPINDWIA KRFAKALGRS *

external links for Arn2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Arn2p

1)	Yun CW, et al. (2000) Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake. J Biol Chem 275(14):10709-15
2)	Heymann P, et al. (1999) Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily. Biometals 12(4):301-6
3)	Yun CW, et al. (2000) Siderophore-iron uptake in saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters. J Biol Chem 275(21):16354-9