ARN1/YHL040C Protein Information Help

Standard Name Arn1p 1
Systematic Name Yhl040cp
ORF Classification Verified
Description ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress (2, 3)
Name Description AFT1 ReguloN 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 627
Molecular Weight (Da) 70,898
Isoelectric Point (pI) 8.25

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Arn1p (InterPro)
Transmembrane Domains There are 13 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B204 | P38731
MIPS: YHL040C
NCBI: 2289869 | 6321747 | 731616 | NP_011823.1
GenBank/EMBL/DDBJ: DAA06646.1 | U11583
External Classifications TC: 2.A.1.16 [The Siderophore-Iron Transporter (SIT) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL
      51  RQNRSLIIQQ TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG
     101  YATSSYSEHS LLSTINVINA VVSAASQIIY ARLSDVFGRL YLFISAVILY
     151  VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV ILILLIILSD FSSLKWRLLY
     201  QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP LSCVPIVLCM
     251  LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS
     301  LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL
     351  PYRLVKDRAV WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA
     401  TLSSFVSTVA SPFFALLVTR CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ
     451  SHSGIIGALC VWGVGTTLFT YPVTVSVQSA VSHENMATVT ALNYTLYRIG
     501  SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF IETYTWGTPQ
     551  RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG
     601  EYVDTKDNDP ILDWFEKLPS KFTFKRE*

external links for Arn1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY GeneMANIA YeastRC Structure Prediction (Seattle)

YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Arn1p
1) Yun CW, et al.  (2000) Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake. J Biol Chem 275(14):10709-15
2) Heymann P, et al.  (2000) Identification and substrate specificity of a ferrichrome-type siderophore transporter (Arn1p) in Saccharomyces cerevisiae. FEMS Microbiol Lett 186(2):221-7
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76