VMR1/YHL035C Protein Information Help

Standard Name Vmr1p 1, 2
Systematic Name Yhl035cp
ORF Classification Verified
Description Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Vacuolar Multidrug Resistance 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,592
Molecular Weight (Da) 180,924
Isoelectric Point (pI) 8.57

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vmr1p (InterPro)
Transmembrane Domains There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052DEF | P38735
MIPS: YHL035C
NCBI: 2289864 | 6321752 | 731612 | NP_011828.1 | NM_001179115.1
GenBank/EMBL/DDBJ: DAA06650.1 | U11583
External Classifications TC: 3.A.1.208 [The Conjugate Transporter-2 (CT2) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MGTDPLIIRN NGSFWEVDDF TRLGRTQLLS YYLPLAIIAS IGIFALCRSG
      51  LSRYVRSAEC DLVNEYLFGA QEERKEDNSI ERLLRNSNTQ ANYVNVKKQG
     101  RILKLRHFDI TTIDVKQIDA KNHGGLTFSR PSTSDHLRKS SEIVLMSLQI
     151  IGLSFLRVTK INIELTNRDV TTLLLFWLIL LSLSILRVYK RSTNLWAICF
     201  TAHTTIWIST WIPIRSVYIG NIDDVPSQIF YIFEFVITST LQPIKLTSPI
     251  KDNSSIIYVR DDHTSPSREH ISSILSCITW SWITNFIWEA QKNTIKLKDI
     301  WGLSMEDYSI FILKGFTRRN KHINNLTLAL FESFKTYLLI GMLWVLVNSI
     351  VNLLPTILMK RFLEIVDNPN RSSSCMNLAW LYIIGMFICR LTLAICNSQG
     401  QFVSDKICLR IRAILIGEIY AKGLRRRLFT SPKTSSDSDS ISANLGTIIN
     451  LISIDSFKVS ELANYLYVTV QAVIMIIVVV GLLFNFLGVS AFAGISIILV
     501  MFPLNFLLAN LLGKFQKQTL KCTDQRISKL NECLQNIRIV KYFAWERNII
     551  NEIKSIRQKE LRSLLKKSLV WSVTSFLWFV TPTLVTGVTF AICTFVQHED
     601  LNAPLAFTTL SLFTLLKTPL DQLSNMLSFI NQSKVSLKRI SDFLRMDDTE
     651  KYNQLTISPD KNKIEFKNAT LTWNENDSDM NAFKLCGLNI KFQIGKLNLI
     701  LGSTGSGKSA LLLGLLGELN LISGSIIVPS LEPKHDLIPD CEGLTNSFAY
     751  CSQSAWLLND TVKNNIIFDN FYNEDRYNKV IDACGLKRDL EILPAGDLTE
     801  IGEKGITLSG GQKQRISLAR AVYSSAKHVL LDDCLSAVDS HTAVWIYENC
     851  ITGPLMKNRT CILVTHNVSL TLRNAHFAIV LENGKVKNQG TITELQSKGL
     901  FKEKYVQLSS RDSINEKNAN RLKAPRKNDS QKIEPVTENI NFDANFVNDG
     951  QLIEEEEKSN GAISPDVYKW YLKFFGGFKA LTALFALYIT AQILFISQSW
    1001  WIRHWVNDTN VRINAPGFAM DTLPLKGMTD SSKNKHNAFY YLTVYFLIGI
    1051  IQAMLGGFKT MMTFLSGMRA SRKIFNNLLD LVLHAQIRFF DVTPVGRIMN
    1101  RFSKDIEGVD QELIPYLEVT IFCLIQCASI IFLITVITPR FLTVAVIVFV
    1151  LYFFVGKWYL TASRELKRLD SITKSPIFQH FSETLVGVCT IRAFGDERRF
    1201  ILENMNKIDQ NNRAFFYLSV TVKWFSFRVD MIGAFIVLAS GSFILLNIAN
    1251  IDSGLAGISL TYAILFTDGA LWLVRLYSTF EMNMNSVERL KEYSSIEQEN
    1301  YLGHDEGRIL LLNEPSWPKD GEIEIENLSL RYAPNLPPVI RNVSFKVDPQ
    1351  SKIGIVGRTG AGKSTIITAL FRLLEPITGC IKIDGQDISK IDLVTLRRSI
    1401  TIIPQDPILF AGTIKSNVDP YDEYDEKKIF KALSQVNLIS SHEFEEVLNS
    1451  EERFNSTHNK FLNLHTEIAE GGLNLSQGER QLLFIARSLL REPKIILLDE
    1501  ATSSIDYDSD HLIQGIIRSE FNKSTILTIA HRLRSVIDYD RIIVMDAGEV
    1551  KEYDRPSELL KDERGIFYSM CRDSGGLELL KQIAKQSSKM MK*

external links for Vmr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Vmr1p
1) Teixeira MC, et al.  (2006) Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid. FEMS Yeast Res 6(2):230-48
2) Wawrzycka D, et al.  (2010) Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae. FEMS Yeast Res 10(7):828-38
3) Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61