DMC1/YER179W Protein Information

Standard Name	Dmc1p 1
Systematic Name	Yer179wp
Alias	Isc2p 2
ORF Classification	Verified
Description	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p (1, 3, 4, 5)
Name Description	Disrupted Meiotic cDNA 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	334
Molecular Weight (Da)	36,612
Isoelectric Point (pI)	5.79

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dmc1p (InterPro)
Physical Interactions	There are 34 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000030744 \| P25453 MIPS: YER179W NCBI: 118683 \| 171401 \| 287608 \| 603420 \| 6321027 \| NP_011106.1 GenBank/EMBL/DDBJ: DAA07842.1 \| D10865 \| M87549 \| U18922

Amino Acid Sequence (or in FASTA format)
1 MSVTGTEIDS DTAKNILSVD ELQNYGINAS DLQKLKSGGI YTVNTVLSTT 51 RRHLCKIKGL SEVKVEKIKE AAGKIIQVGF IPATVQLDIR QRVYSLSTGS 101 KQLDSILGGG IMTMSITEVF GEFRCGKTQM SHTLCVTTQL PREMGGGEGK 151 VAYIDTEGTF RPERIKQIAE GYELDPESCL ANVSYARALN SEHQMELVEQ 201 LGEELSSGDY RLIVVDSIMA NFRVDYCGRG ELSERQQKLN QHLFKLNRLA 251 EEFNVAVFLT NQVQSDPGAS ALFASADGRK PIGGHVLAHA SATRILLRKG 301 RGDERVAKLQ DSPDMPEKEC VYVIGEKGIT DSSD*

Amino Acid Sequence (or in FASTA format)

       1  MSVTGTEIDS DTAKNILSVD ELQNYGINAS DLQKLKSGGI YTVNTVLSTT
      51  RRHLCKIKGL SEVKVEKIKE AAGKIIQVGF IPATVQLDIR QRVYSLSTGS
     101  KQLDSILGGG IMTMSITEVF GEFRCGKTQM SHTLCVTTQL PREMGGGEGK
     151  VAYIDTEGTF RPERIKQIAE GYELDPESCL ANVSYARALN SEHQMELVEQ
     201  LGEELSSGDY RLIVVDSIMA NFRVDYCGRG ELSERQQKLN QHLFKLNRLA
     251  EEFNVAVFLT NQVQSDPGAS ALFASADGRK PIGGHVLAHA SATRILLRKG
     301  RGDERVAKLQ DSPDMPEKEC VYVIGEKGIT DSSD*

external links for Dmc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Dmc1p

1)	Bishop DK, et al. (1992) DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69(3):439-56
2)	Kobayashi T, et al. (1993) Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant. Mol Gen Genet 237(1-2):225-32
3)	Schwacha A and Kleckner N (1997) Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway. Cell 90(6):1123-35
4)	Symington LS (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66(4):630-70, table of contents
5)	Nimonkar AV, et al. (2012) Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination. J Biol Chem 287(34):28727-37