RAD24/YER173W Protein Information Help

Standard Name Rad24p 1
Systematic Name Yer173wp
ORF Classification Verified
Description Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein (2, 3, 4) Also known as: RS1
Name Description RADiation sensitive
Experimental Data
Molecules/cell 752 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 659
Molecular Weight (Da) 75,726
Isoelectric Point (pI) 6.35

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rad24p (InterPro)
Physical Interactions There are 46 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013301D | P32641
MIPS: YER173W
NCBI: 418428 | 603414 | 6321021 | NP_011100.1
GenBank/EMBL/DDBJ: DAA07835.1 | U18922
Amino Acid Sequence (or in FASTA format)
 
       1  MDSTNLNKRP LLQYSLSSLG SQITKWSSSR PTSPVRKARS TENDFLSKQD
      51  TSSILPSIND DGGEQWYEKF KPNCLEQVAI HKRKLKDVQE ALDAMFLPNA
     101  KHRILLLSGP SGCSKSTVIK ELSKILVPKY RQNSNGTSFR STPNEHKVTE
     151  FRGDCIVNDL PQMESFSEFL KGARYLVMSN LSLILIEDLP NVFHIDTRRR
     201  FQQLILQWLY SSEPLLPPLV ICITECEIPE NDNNYRKFGI DYTFSAETIM
     251  NKEILMHPRL KRIKFNPINS TLLKKHLKFI CVQNMKMLKE KNKWNKRQEV
     301  IDYIAQETGD IRSAITTLQF WATSSGSLPI STRESTISYF HAIGKVIHGS
     351  HSTNNDNEMI NNLFENSNNL LSKEDFKLGI LENYNTFNKG EFSISDASSI
     401  VDCLSECDNM NGLPESNEYG LREVRKTFRN ISKQGHNHGT VYFPREWKVR
     451  KLQNSFKVQA EDWLNVSLYK YNAVHSFRNI TLEFGYYAPL IRKCQSYKKK
     501  YILYYLKNLP SGSSGPKQTM DKFSDIMKVE NGIDVVDRIG GPIEALSVED
     551  GLAPLMDNDS NNCDHLEDQK KERDRRLRML IDQYERNVMM ANDDLEDEET
     601  SFNDDPIVDS DSDNSNNIGN ETFGRSDEDE SLCEILSQRQ PRKAPVISES
     651  LSDSDLEIL*

external links for Rad24p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rad24p
1) Eckardt, F. and Game, J.  (1985) Personal Communication, Mortimer Map Edition 9
2) Lydall D, et al.  (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383(6603):840-3
3) Majka J and Burgers PM  (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54
4) Shinohara M, et al.  (2003) The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Genetics 164(3):855-65
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41