ADK2/YER170W Protein Information

Standard Name	Adk2p 1
Systematic Name	Yer170wp
Alias	Aky3p 2 , Pak3p 2
ORF Classification	Verified
Description	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background (3)
Name Description	ADenylate Kinase 1

Experimental Data
Molecules/cell	704 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	225
Molecular Weight (Da)	25,194
Isoelectric Point (pI)	9.76

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Adk2p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DB95 \| P26364 MIPS: YER170W NCBI: 125155 \| 171046 \| 398365067 \| 4097 \| 45270804 \| 603411 \| NP_011097.3 GenBank/EMBL/DDBJ: DAA07832.1 \| AY558457 \| M77757 \| U18922 \| X65126
External Classifications	EC: 2.7.4.3 [Adenylate kinase]

Amino Acid Sequence (or in FASTA format)
1 MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL 51 RQEIKSESTL GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL 101 LDGFPRTTAQ ASALDELLKQ HDASLNLVVE LDVPESTILE RIENRYVHVP 151 SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD DTAEVFKKRL EEYKKTNEPL 201 KDYYKKSGIF GTVSGETSDI IFRNY*

Amino Acid Sequence (or in FASTA format)

       1  MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL
      51  RQEIKSESTL GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL
     101  LDGFPRTTAQ ASALDELLKQ HDASLNLVVE LDVPESTILE RIENRYVHVP
     151  SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD DTAEVFKKRL EEYKKTNEPL
     201  KDYYKKSGIF GTVSGETSDI IFRNY*

external links for Adk2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Adk2p

1)	Cooper AJ and Friedberg EC (1992) A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae. Gene 114(1):145-8
2)	Schricker R, et al. (1995) Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae. J Biol Chem 270(52):31103-10
3)	Gu Y, et al. (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J Biol Chem 280(19):18604-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41