YER130C Protein Information

Systematic Name	Yer130cp
ORF Classification	Uncharacterized
Description	Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress (1, 2, 3, 4, 5, 6)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	443
Molecular Weight (Da)	50,319
Isoelectric Point (pI)	5.59

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yer130cp (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013ACC3 \| P39959 MIPS: YER130C NCBI: 1384129 \| 1723598 \| 6320977 \| NP_011056.1 GenBank/EMBL/DDBJ: DAA07790.1 \| U18916

Amino Acid Sequence (or in FASTA format)
1 MSLYPLQRFE SNDTVFSYTL NSKTELFNES RNNDKQHFTL QLIPNANANA 51 KEIDNNNVEI INDLTGNTIV DNCVTTATSS NQLERRLSIS DYRTENGNYY 101 EYEFFGRREL NEPLFNNDIV ENDDDIDLNN ESDVLMVSDD ELEVNERFSF 151 LKQQPLDGLN RISSTNNLKN LEIHEFIIDP TENIDDELED SFTTVPQSKK 201 KVRDYFKLNI FGSSSSSNNN SNSLGCEPIQ TENSSSQKMF KNRFFRSRKS 251 TLIKSLPLEQ ENEVLINSGF DVSSNEESDE SDHAIINPLK LVGNNKDIST 301 QSIAKTTNPF KSGSDFKMIE PVSKFSNDSR KDLLAAISEP SSSPSPSAPS 351 PSVQSSSSSH GLVVRKKTGS MQKTRGRKPS LIPDASKQFG CEFCDRRFKR 401 QEHLKRHVRS LHMCEKPFTC HICNKNFSRS DNLNQHVKTH ASL*

Amino Acid Sequence (or in FASTA format)

       1  MSLYPLQRFE SNDTVFSYTL NSKTELFNES RNNDKQHFTL QLIPNANANA
      51  KEIDNNNVEI INDLTGNTIV DNCVTTATSS NQLERRLSIS DYRTENGNYY
     101  EYEFFGRREL NEPLFNNDIV ENDDDIDLNN ESDVLMVSDD ELEVNERFSF
     151  LKQQPLDGLN RISSTNNLKN LEIHEFIIDP TENIDDELED SFTTVPQSKK
     201  KVRDYFKLNI FGSSSSSNNN SNSLGCEPIQ TENSSSQKMF KNRFFRSRKS
     251  TLIKSLPLEQ ENEVLINSGF DVSSNEESDE SDHAIINPLK LVGNNKDIST
     301  QSIAKTTNPF KSGSDFKMIE PVSKFSNDSR KDLLAAISEP SSSPSPSAPS
     351  PSVQSSSSSH GLVVRKKTGS MQKTRGRKPS LIPDASKQFG CEFCDRRFKR
     401  QEHLKRHVRS LHMCEKPFTC HICNKNFSRS DNLNQHVKTH ASL*

external links for Yer130cp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Yer130cp

1)	Vachova L, et al. (2004) Sok2p transcription factor is involved in adaptive program relevant for long term survival of Saccharomyces cerevisiae colonies. J Biol Chem 279(36):37973-81
2)	Fernandes AR, et al. (2005) Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Biochem Biophys Res Commun 337(1):95-103
3)	De Nicola R, et al. (2007) Physiological and Transcriptional Responses of Saccharomyces cerevisiae to Zinc Limitation in Chemostat Cultures. Appl Environ Microbiol 73(23):7680-92
4)	Ramsdale M, et al. (2008) MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell 19(10):4393-403
5)	Mira NP, et al. (2010) Genomic Expression Program Involving the Haa1p-Regulon in Saccharomyces cerevisiae Response to Acetic Acid. OMICS 14(5):587-601
6)	Yang Y, et al. (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8
7)	Petryshyn A, et al. (2008) personal communication