KAP123/YER110C Protein Information Help

Standard Name Kap123p
Systematic Name Yer110cp
Alias Yrb4p
ORF Classification Verified
Description Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 (1, 2, 3)
Name Description KAryoPherin
Experimental Data
Molecules/cell 38300 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,113
Molecular Weight (Da) 122,600
Isoelectric Point (pI) 4.36

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kap123p (InterPro)
Physical Interactions There are 202 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E31 | P40069
MIPS: YER110C
NCBI: 603349 | 6320956 | 731502 | NP_011035.1
GenBank/EMBL/DDBJ: DAA07770.1 | U18916
Amino Acid Sequence (or in FASTA format)
 
       1  MDQQFLSQLE QTLHAITSGV GLKEATKTLQ TQFYTQPTTL PALIHILQNG
      51  SDDSLKQLAG VEARKLVSKH WNAIDESTRA SIKTSLLQTA FSEPKENVRH
     101  SNARVIASIG TEELDGNKWP DLVPNLIQTA SGEDVQTRQT AIFILFSLLE
     151  DFTSSLSGHI DDFLALFSQT INDPSSLEIR SLSAQALNHV SALIEEQETI
     201  NPVQAQKFAA SIPSVVNVLD AVIKADDTMN AKLIFNCLND FLLLDSQLTG
     251  NFIVDLIKLS LQIAVNSEID EDVRVFALQF IISSLSYRKS KVSQSKLGPE
     301  ITVAALKVAC EEIDVDDELN NEDETGENEE NTPSSSAIRL LAFASSELPP
     351  SQVASVIVEH IPAMLQSANV FERRAILLAI SVAVTGSPDY ILSQFDKIIP
     401  ATINGLKDTE PIVKLAALKC IHQLTTDLQD EVAKFHEEYL PLIIDIIDSA
     451  KNIVIYNYAT VALDGLLEFI AYDAIAKYLD PLMNKLFYML ESNESSKLRC
     501  AVVSAIGSAA FAAGSAFIPY FKTSVHYLEK FIQNCSQIEG MSEDDIELRA
     551  NTFENISTMA RAVRSDAFAE FAEPLVNSAY EAIKTDSARL RESGYAFIAN
     601  LAKVYGENFA PFLKTILPEI FKTLELDEYQ FNFDGDAEDL AAFADSANEE
     651  ELQNKFTVNT GISYEKEVAS AALSELALGT KEHFLPYVEQ SLKVLNEQVD
     701  ESYGLRETAL NTIWNVVKSV LLASKVEPES YPKGIPASSY VNADVLAVIQ
     751  AARETSMGNL SDEFETSMVI TVMEDFANMI KQFGAIIIMD NGDSSMLEAL
     801  CMQVLSVLKG THTCQTIDIE EDVPRDEELD ASETEATLQD VALEVLVSLS
     851  QALAGDFAKV FDNFRPVVFG LFQSKSKNKR SSAVGAASEL ALGMKEQNPF
     901  VHEMLEALVI RLTSDKSLEV RGNAAYGVGL LCEYASMDIS AVYEPVLKAL
     951  YELLSAADQK ALAAEDDEAT REIIDRAYAN ASGCVARMAL KNSALVPLEQ
    1001  TVPALLAHLP LNTGFEEYNP IFELIMKLYQ ENSPVITNET PRIIEIFSAV
    1051  FTKENDRIKL EKESTLGREE NMERLKQFQT EEMKHKVIEL LKYLNTTYNG
    1101  IVAQNPVLAA VIA*

external links for Kap123p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Kap123p
1) Schlenstedt G, et al.  (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49
2) Sydorskyy Y, et al.  (2003) Intersection of the Kap123p-mediated nuclear import and ribosome export pathways. Mol Cell Biol 23(6):2042-54
3) Mosammaparast N, et al.  (2002) Pathways mediating the nuclear import of histones H3 and H4 in yeast. J Biol Chem 277(1):862-8
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41