FLO8/YER109C Protein Information Help

Standard Name Flo8p 1, 2
Systematic Name Yer109cp
Alias Phd5p 3 , Yer108cp , Sta10p 4
ORF Classification Verified
Description Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a nonsense mutation in this gene (1, 2, 5)
Name Description FLOcculation
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 798
Molecular Weight (Da) 86,648
Isoelectric Point (pI) 10.12

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Flo8p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012AA15 | P40068
MIPS: YER109C
NCBI: 1213591 | 2506904 | 3645900 | 398364683 | 603347 | 603348 | NP_011034.3 | NM_001178999.3
GenBank/EMBL/DDBJ: DAA07769.1 | D83713 | U18916 | U51431
Amino Acid Sequence (or in FASTA format)
 
       1  MSYKVNSSYP DSIPPTEQPY MASQYKQDLQ SNIAMATNSE QQRQQQQQQQ
      51  QQQQQWINQP TAENSDLKEK MNCKNTLNEY IFDFLTKSSL KNTAAAFAQD
     101  AHLDRDKGQN PVDGPKSKEN NGNQNTFSKV VDTPQGFLYE W*QIFWDIFN
     151  TSSSRGGSEF AQQYYQLVLQ EQRQEQIYRS LAVHAARLQH DAERRGEYSN
     201  EDIDPMHLAA MMLGNPMAPA VQMRNVNMNP IPIPMVGNPI VNNFSIPPYN
     251  NANPTTGATA VAPTAPPSGD FTNVGPTQNR SQNVTGWPVY NYPMQPTTEN
     301  PVGNPCNNNT TNNTTNNKSP VNQPKSLKTM HSTDKPNNVP TSKSTRSRSA
     351  TSKAKGKVKA GLVAKRRRKN NTATVSAGST NACSPNITTP GSTTSEPAMV
     401  GSRVNKTPRS DIATNFRNQA IIFGEEDIYS NSKSSPSLDG ASPSALASKQ
     451  PTKVRKNTKK ASTSAFPVES TNKLGGNSVV TGKKRSPPNT RVSRRKSTPS
     501  VILNADATKD ENNMLRTFSN TIAPNIHSAP PTKTANSLPF PGINLGSFNK
     551  PAVSSPLSSV TESCFDPESG KIAGKNGPKR AVNSKVSASS PLSIATPRSG
     601  DAQKQRSSKV PGNVVIKPPH GFSTTNLNIT LKNSKIITSQ NNTVSQELPN
     651  GGNILEAQVG NDSRSSKGNR NTLSTPEEKK PSSNNQGYDF DALKNSSSLL
     701  FPNQAYASNN RTPNENSNVA DETSASTNSG DNDNTLIQPS SNVGTTLGPQ
     751  QTSTNENQNV HSQNLKFGNI GMVEDQGPDY DLNLLDTNEN DFNFINWEG*

external links for Flo8p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome


DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Flo8p
1) Kobayashi O, et al.  (1996) Molecular cloning and analysis of the dominant flocculation gene FLO8 from Saccharomyces cerevisiae. Mol Gen Genet 251(6):707-15
2) Liu H, et al.  (1996) Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144(3):967-78
3) Gimeno CJ and Fink GR  (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
4) Kim TS, et al.  (2003) STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae. Curr Genet 44(5):261-7
5) Rupp S, et al.  (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69