GLE2/YER107C Protein Information

Standard Name	Gle2p 1
Systematic Name	Yer107cp
Alias	Rae1p
ORF Classification	Verified
Description	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 (1, 2, 3, 4)
Name Description	GLFG LEthal 1

Experimental Data
Molecules/cell	1820 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	365
Molecular Weight (Da)	40,522
Isoelectric Point (pI)	8.49

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gle2p (InterPro)
Physical Interactions	There are 51 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053299 \| P40066 MIPS: YER107C NCBI: 398364677 \| 51013219 \| 603345 \| 731499 \| NP_011033.3 \| NM_001178998.3 GenBank/EMBL/DDBJ: DAA07768.1 \| AY692884 \| U18839

Amino Acid Sequence (or in FASTA format)
1 MSFFNRSNTT SALGTSTAMA NEKDLANDIV INSPAEDSIS DIAFSPQQDF 51 MFSASSWDGK VRIWDVQNGV PQGRAQHESS SPVLCTRWSN DGTKVASGGC 101 DNALKLYDIA SGQTQQIGMH SAPIKVLRFV QCGPSNTECI VTGSWDKTIK 151 YWDMRQPQPV STVMMPERVY SMDNKQSLLV VATAERHIAI INLANPTTIF 201 KATTSPLKWQ TRCVACYNEA DGYAIGSVEG RCSIRYIDDG MQKKSGFSFK 251 CHRQTNPNRA PGSNGQSLVY PVNSIAFHPL YGTFVTAGGD GTFNFWDKNQ 301 RHRLKGYPTL QASIPVCSFN RNGSVFAYAL SYDWHQGHMG NRPDYPNVIR 351 LHATTDEEVK EKKKR*

Amino Acid Sequence (or in FASTA format)

       1  MSFFNRSNTT SALGTSTAMA NEKDLANDIV INSPAEDSIS DIAFSPQQDF
      51  MFSASSWDGK VRIWDVQNGV PQGRAQHESS SPVLCTRWSN DGTKVASGGC
     101  DNALKLYDIA SGQTQQIGMH SAPIKVLRFV QCGPSNTECI VTGSWDKTIK
     151  YWDMRQPQPV STVMMPERVY SMDNKQSLLV VATAERHIAI INLANPTTIF
     201  KATTSPLKWQ TRCVACYNEA DGYAIGSVEG RCSIRYIDDG MQKKSGFSFK
     251  CHRQTNPNRA PGSNGQSLVY PVNSIAFHPL YGTFVTAGGD GTFNFWDKNQ
     301  RHRLKGYPTL QASIPVCSFN RNGSVFAYAL SYDWHQGHMG NRPDYPNVIR
     351  LHATTDEEVK EKKKR*

external links for Gle2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Gle2p

1)	Murphy R, et al. (1996) GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function. Mol Biol Cell 7(12):1921-37
2)	Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
3)	Izawa S, et al. (2004) Gle2p is essential to induce adaptation of the export of bulk poly(A)+ mRNA to heat shock in Saccharomyces cerevisiae. J Biol Chem 279(34):35469-78
4)	Lutzmann M, et al. (2005) Reconstitution of Nup157 and Nup145N into the Nup84 complex. J Biol Chem 280(18):18442-51
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41