SER3/YER081W Protein Information Help

Standard Name Ser3p
Systematic Name Yer081wp
ORF Classification Verified
Description 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication (1, 2)
Name Description SERine requiring 1
Experimental Data
Molecules/cell 7670 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 469
Molecular Weight (Da) 51,193
Isoelectric Point (pI) 5.37

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ser3p (InterPro)
Physical Interactions There are 32 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E54 | P40054
MIPS: YER081W
NCBI: 398364547 | 603319 | 731484 | NP_011004.3
GenBank/EMBL/DDBJ: DAA07742.1 | U18839
External Classifications EC: 1.1.1.95 [Phosphoglycerate dehydrogenase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTSIDINNLQ NTFQQAMNMS GSPGAVCTSP TQSFMNTVPQ RLNAVKHPKI
      51  LKPFSTGDMK ILLLENVNQT AITIFEEQGY QVEFYKSSLP EEELIEKIKD
     101  VHAIGIRSKT RLTSNVLQHA KNLVCIGCFC IGTNQVDLDY ATSRGIAVFN
     151  SPFSNSRSVA ELVIAEIISL ARQLGDRSIE LHTGTWNKVA ARCWEVRGKT
     201  LGIIGYGHIG SQLSVLAEAM GLHVLYYDIV TIMALGTARQ VSTLDELLNK
     251  SDFVTLHVPA TPETEKMLSA PQFAAMKDGA YVINASRGTV VDIPSLIQAV
     301  KANKIAGAAL DVYPHEPAKN GEGSFNDELN SWTSELVSLP NIILTPHIGG
     351  STEEAQSSIG IEVATALSKY INEGNSVGSV NFPEVALKSL SYDQENTVRV
     401  LYIHQNVPGV LKTVNDILSN HNIEKQFSDS NGEIAYLMAD ISSVDQSDIK
     451  DIYEQLNQTS AKISIRLLY*

external links for Ser3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ser3p
1) Albers E, et al.  (2003) Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. J Biol Chem 278(12):10264-72
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41