ICL1/YER065C Protein Information Help

Standard Name Icl1p
Systematic Name Yer065cp
ORF Classification Verified
Description Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose (1, 2)
Name Description IsoCitrate Lyase
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 557
Molecular Weight (Da) 62,408
Isoelectric Point (pI) 6.38

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Icl1p (InterPro)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530BA | P28240
MIPS: YER065C
NCBI: 113033 | 3808 | 3810 | 398364491 | 603301 | NP_010987.3 | NM_001178956.3
GenBank/EMBL/DDBJ: DAA07724.1 | U18813 | X61271 | X65554
External Classifications EC: 4.1.3.1 [Isocitrate lyase]
Amino Acid Sequence (or in FASTA format)
 
       1  MPIPVGNTKN DFAALQAKLD ADAAEIEKWW SDSRWSKTKR NYSARDIAVR
      51  RGTFPPIEYP SSVMARKLFK VLEKHHNEGT VSKTFGALDP VQISQMAKYL
     101  DTIYISGWQC SSTASTSNEP GPDLADYPMD TVPNKVEHLF KAQLFHDRKQ
     151  LEARSKAKSQ EELDEMGAPI DYLTPIVADA DAGHGGLTAV FKLTKMFIER
     201  GAAGIHMEDQ TSTNKKCGHM AGRCVIPVQE HVNRLVTIRM CADIMHSDLI
     251  VVARTDSEAA TLISSTIDTR DHYFIVGATN PNIEPFAEVL NDAIMSGASG
     301  QELADIEQKW CRDAGLKLFH EAVIDEIERS ALSNKQELIK KFTSKVGPLT
     351  ETSHREAKKL AKEILGHEIF FDWELPRVRE GLYRYRGGTQ CSIMRARAFA
     401  PYADLVWMES NYPDFQQAKE FAEGVKEKFP DQWLAYNLSP SFNWPKAMSV
     451  DEQHTFIQRL GDLGYIWQFI TLAGLHTNAL AVHNFSRDFA KDGMKAYAQN
     501  VQQREMDDGV DVLKHQKWSG AEYIDGLLKL AQGGVSATAA MGTGVTEDQF
     551  KENGVKK*

external links for Icl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Icl1p
1) Fernandez E, et al.  (1992) The ICL1 gene from Saccharomyces cerevisiae. Eur J Biochem 204(3):983-90
2) Luttik MA, et al.  (2000) The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. J Bacteriol 182(24):7007-13