VHR2/YER064C Protein Information

Standard Name	Vhr2p 1
Systematic Name	Yer064cp
ORF Classification	Verified
Description	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress (2, 3, 4)
Name Description	VHt1 Regulator 1

Experimental Data
Molecules/cell	1730 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	505
Molecular Weight (Da)	56,638
Isoelectric Point (pI)	9.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Vhr2p (InterPro)
Physical Interactions	There are 21 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013ACA6 \| P40041 MIPS: YER064C NCBI: 603300 \| 6320907 \| 731472 \| NP_010986.1 GenBank/EMBL/DDBJ: DAA07723.1 \| U18813

Amino Acid Sequence (or in FASTA format)
1 MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL 51 ELIDSFGLSQ HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ 101 SVRRNRKRSK KKLLDSKKKI ARGKVQKIPL SPPSSSNMGS CSASNASSSD 151 EEASVKEEPA EHALPSLNTI TSQKLLPYPN GRTLPPVPTQ VRSLLKKNAS 201 LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI IVEIVNNAIP 251 LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK 301 DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE 351 FLTILSQRLF MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP 401 INEIIYHMTL HQYPLVCSNK QSNPMRPHST SEVLSAHSST KDASTPGKEE 451 PRVTRSSTSA DSTIITLPSI EVPNTYDDDR LKMLSAISLQ IENSTFSKPF 501 STISK*

Amino Acid Sequence (or in FASTA format)

       1  MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL
      51  ELIDSFGLSQ HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ
     101  SVRRNRKRSK KKLLDSKKKI ARGKVQKIPL SPPSSSNMGS CSASNASSSD
     151  EEASVKEEPA EHALPSLNTI TSQKLLPYPN GRTLPPVPTQ VRSLLKKNAS
     201  LLRDPSAPYA HGGDEKLQKF DIEDQPLESE QEYDFIAKSI IVEIVNNAIP
     251  LPEQIQRDKF IRPNLTKKKG CQSKVVISNN LRKLILSKIH NSRTCLEMSK
     301  DERNLDSFAN LETLGKNSLM ASISLVVENS FSHLPSSTKQ YLTERLSSIE
     351  FLTILSQRLF MPATRQLFAD LSQEKIQVRV LNLILGSLVK DYGFDASLAP
     401  INEIIYHMTL HQYPLVCSNK QSNPMRPHST SEVLSAHSST KDASTPGKEE
     451  PRVTRSSTSA DSTIITLPSI EVPNTYDDDR LKMLSAISLQ IENSTFSKPF
     501  STISK*

external links for Vhr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Vhr2p

1)	Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125
2)	Kennedy MA and Bard M (2001) Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Biochim Biophys Acta 1517(2):177-89
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41