HOR2/YER062C Protein Information

Standard Name	Hor2p
Systematic Name	Yer062cp
Alias	Gpp2p 1
ORF Classification	Verified
Description	Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	HyperOsmolarity-Responsive 3

Experimental Data
Molecules/cell	5000 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	250
Molecular Weight (Da)	27,814
Isoelectric Point (pI)	6.07

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hor2p (InterPro)
Physical Interactions	There are 26 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000037A2C \| P40106 MIPS: YER062C NCBI: 1236746 \| 398364483 \| 603298 \| 731470 \| NP_010984.3 GenBank/EMBL/DDBJ: DAA07721.1 \| D50469 \| U18813
External Classifications	EC: 3.1.3.- [Phosphoric Monoester Hydrolases] EC: 3.1.3.21 [Glycerol-1-phosphatase]

Amino Acid Sequence (or in FASTA format)
1 MGLTTKPLSL KVNAALFDVD GTIIISQPAI AAFWRDFGKD KPYFDAEHVI 51 QVSHGWRTFD AIAKFAPDFA NEEYVNKLEA EIPVKYGEKS IEVPGAVKLC 101 NALNALPKEK WAVATSGTRD MAQKWFEHLG IRRPKYFITA NDVKQGKPHP 151 EPYLKGRNGL GYPINEQDPS KSKVVVFEDA PAGIAAGKAA GCKIIGIATT 201 FDLDFLKEKG CDIIVKNHES IRVGGYNAET DEVEFIFDDY LYAKDDLLKW 251 *

Amino Acid Sequence (or in FASTA format)

       1  MGLTTKPLSL KVNAALFDVD GTIIISQPAI AAFWRDFGKD KPYFDAEHVI
      51  QVSHGWRTFD AIAKFAPDFA NEEYVNKLEA EIPVKYGEKS IEVPGAVKLC
     101  NALNALPKEK WAVATSGTRD MAQKWFEHLG IRRPKYFITA NDVKQGKPHP
     151  EPYLKGRNGL GYPINEQDPS KSKVVVFEDA PAGIAAGKAA GCKIIGIATT
     201  FDLDFLKEKG CDIIVKNHES IRVGGYNAET DEVEFIFDDY LYAKDDLLKW
     251  *

external links for Hor2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hor2p

1)	Norbeck J, et al. (1996) Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J Biol Chem 271(23):13875-81
2)	Boy-Marcotte E, et al. (1998) Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae. J Bacteriol 180(5):1044-52
3)	Hirayama T, et al. (1995) Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol Gen Genet 249(2):127-38
4)	Pahlman AK, et al. (2001) The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. J Biol Chem 276(5):3555-63
5)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41