PCL6/YER059W Protein Information

Standard Name	Pcl6p
Systematic Name	Yer059wp
ORF Classification	Verified
Description	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	Pho85 CycLin 1

Experimental Data
Molecules/cell	1240 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	420
Molecular Weight (Da)	47,007
Isoelectric Point (pI)	6.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pcl6p (InterPro)
Physical Interactions	There are 23 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013ACA3 \| P40038 MIPS: YER059W NCBI: 603295 \| 6320901 \| 731468 \| NP_010980.1 GenBank/EMBL/DDBJ: DAA07717.1 \| U18813

Amino Acid Sequence (or in FASTA format)
1 MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR 51 RDIVVVTRVA SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH 101 GSNMNTINKY YPVRFPKNNE RQLSDTNNLN EKVQGTHTVQ SSTQEDKILD 151 GDTSNSQVTP SLNIAEFPTD KLLKMLTALL TKIIKSNDRT AATNPSLTQE 201 IENGRCLALS DNEKKYLSPV LGFRGKHVPQ IGLDQYFQRI QKYCPTTNDV 251 FLSLLVYFDR ISKRCNSVTT TPKTNTAKHE SPSNESSLDK ANRGADKMSA 301 CNSNENNEND DSDDENTGVQ RDSRAHPQMF VMDSHNIHRL IIAGITVSTK 351 FLSDFFYSNS RYSRVGGISL QELNHLELQF LVLCDFELLI SVNELQRYAD 401 LLYRFWNNAK AQSQALVTGM *

Amino Acid Sequence (or in FASTA format)

       1  MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR
      51  RDIVVVTRVA SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH
     101  GSNMNTINKY YPVRFPKNNE RQLSDTNNLN EKVQGTHTVQ SSTQEDKILD
     151  GDTSNSQVTP SLNIAEFPTD KLLKMLTALL TKIIKSNDRT AATNPSLTQE
     201  IENGRCLALS DNEKKYLSPV LGFRGKHVPQ IGLDQYFQRI QKYCPTTNDV
     251  FLSLLVYFDR ISKRCNSVTT TPKTNTAKHE SPSNESSLDK ANRGADKMSA
     301  CNSNENNEND DSDDENTGVQ RDSRAHPQMF VMDSHNIHRL IIAGITVSTK
     351  FLSDFFYSNS RYSRVGGISL QELNHLELQF LVLCDFELLI SVNELQRYAD
     401  LLYRFWNNAK AQSQALVTGM *

external links for Pcl6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pcl6p

1)	Measday V, et al. (1997) A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol Cell Biol 17(3):1212-23
2)	Wang Z, et al. (2001) The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. FEBS Lett 506(3):277-80
3)	Hyman LE, et al. (2002) Binding to Elongin C inhibits degradation of interacting proteins in yeast. J Biol Chem 277(18):15586-91
4)	Shi XZ and Ao SZ (2002) Analysis of phosphorylation of YJL084c, a yeast protein. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34(4):433-8
5)	Tan YS, et al. (2003) Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. J Biol Chem 278(1):147-53
6)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41