HMF1/YER057C Protein Information Help

Standard Name Hmf1p
Systematic Name Yer057cp
Alias Hig1p
ORF Classification Verified
Description Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication (1, 2, 3)
Name Description Homologous Mmf1p Factor 1
Experimental Data
Molecules/cell 672 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 129
Molecular Weight (Da) 13,906
Isoelectric Point (pI) 5.19

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hmf1p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000111F04 | P40037
MIPS: YER057C
NCBI: 12082320 | 14719469 | 14719470 | 14719471 | 14719472 | 14719473 | 14719474 | 398364461 | 45270802 | 603293 | 731467 | NP_010978.3
GenBank/EMBL/DDBJ: DAA07715.1 | AB050475 | AY558456 | U18813
Amino Acid Sequence (or in FASTA format)
 
       1  MVTTLTPVIC ESAPAAAASY SHAMKVNNLI FLSGQIPVTP DNKLVEGSIA
      51  DKAEQVIQNI KNVLEASNSS LDRVVKVNIF LADINHFAEF NSVYAKYFNT
     101  HKPARSCVAV AALPLGVDME MEAIAAERD*

external links for Hmf1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hmf1p
1) Oxelmark E, et al.  (2000) Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Mol Cell Biol 20(20):7784-97
2) Deaconescu AM, et al.  (2002) X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Proteins 48(2):431-6
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41