HIS1/YER055C Protein Information

Standard Name	His1p 1, 2
Systematic Name	Yer055cp
ORF Classification	Verified
Description	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control (3, 4, 5)
Name Description	HIStidine 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	297
Molecular Weight (Da)	32,266
Isoelectric Point (pI)	5.99

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with His1p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012C763 \| P00498 MIPS: YER055C NCBI: 123137 \| 3773 \| 398364453 \| 603291 \| NP_010975.3 GenBank/EMBL/DDBJ: DAA07712.1 \| U18813 \| V01306
External Classifications	EC: 2.4.2.17 [ATP phosphoribosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MDLVNHLTDR LLFAIPKKGR LYSKSVSILN GADITFHRSQ RLDIALSTSL 51 PVALVFLPAA DIPTFVGEGK CDLGITGVDQ VRESNVDVDL AIDLQFGNCK 101 LQVQVPVNGE YKKPEQLIGK TIVTSFVKLA EKYFADLEGT TVEKMTTRIK 151 FVSGSVEASC ALGIGDAIVD LVESGETMRA AGLVDIATVL STSAYLIESK 201 NPKSDKSLIA TIKSRIEGVM TAQRFVSCIY NAPEDKLPEL LKVTPGRRAP 251 TISKIDDEGW VAVSSMIERK TKGVVLDELK RLGASDIMVF EISNCRV*

Amino Acid Sequence (or in FASTA format)

       1  MDLVNHLTDR LLFAIPKKGR LYSKSVSILN GADITFHRSQ RLDIALSTSL
      51  PVALVFLPAA DIPTFVGEGK CDLGITGVDQ VRESNVDVDL AIDLQFGNCK
     101  LQVQVPVNGE YKKPEQLIGK TIVTSFVKLA EKYFADLEGT TVEKMTTRIK
     151  FVSGSVEASC ALGIGDAIVD LVESGETMRA AGLVDIATVL STSAYLIESK
     201  NPKSDKSLIA TIKSRIEGVM TAQRFVSCIY NAPEDKLPEL LKVTPGRRAP
     251  TISKIDDEGW VAVSSMIERK TKGVVLDELK RLGASDIMVF EISNCRV*

external links for His1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for His1p

1)	Savage, E. (1979) A comparative analysis of recombination at the his1 locus among five related diploid strains of Saccharomyces cerevisiae. Ph.D Thesis
2)	Korch CT and Snow R (1973) Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. I. Characteristics of Mutants and Genetic Mapping of Alleles. Genetics 74(2):287-305
3)	Hinnebusch AG and Fink GR (1983) Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. J Biol Chem 258(8):5238-47
4)	Pearce DA and Sherman F (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
5)	Alifano P, et al. (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69