GIP2/YER054C Protein Information

Standard Name	Gip2p 1
Systematic Name	Yer054cp
ORF Classification	Verified
Description	Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Glc7-Interacting Protein 1

Experimental Data
Molecules/cell	125 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	548
Molecular Weight (Da)	62,318
Isoelectric Point (pI)	9.4

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gip2p (InterPro)
Physical Interactions	There are 26 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012B4BA \| P40036 MIPS: YER054C NCBI: 603290 \| 6320895 \| 731466 \| NP_010974.1 GenBank/EMBL/DDBJ: DAA07711.1 \| U18813

Amino Acid Sequence (or in FASTA format)
1 MYIKAEQKPQ QFERKNEKLD RNKNQQLPDL ETDFKGYRVN SDLYNKERDG 51 STEETLNSLK FLHKPQRVTQ MRANRFPEEE VQRNTDLNKR IFSAGNDENV 101 DNESGWSKIA AAKNHTSVES LNGSTRPPFK IELPPLSPKS TVPKSFQAEY 151 PEAKSPGNDM NFEYDEEILI PFAPPVYKKS GELLKSSLKR RSKSLPTTPG 201 IRSGNGVQAR DGSPMLIRSK SVHFDQAAPV KYFAEDESPI NVNKTEQHDN 251 CLSFKHKPVN LMVDPEEETK MLSSGLETTS IDDDLTTVAP KGFAHPAKIS 301 NPNNGKGTNN TKLRKSKRFQ NLLKNRTDMP PSKSNKKFVN GGGAHEISDR 351 NSKNYHVVGL YSKNFPILSN KNPKSLKLNI FINLSQNKKV FLQELSLYIH 401 RDNNYFSNSS SFYNIPNSHN GNDCNGVAKG YNAGCTRLIA GRILVKNIFY 451 DKRVVVRYTW DSWRTTHEVE CVYISDGDGI LPGTNMDIFH FIIDDVSKVD 501 PRGKLEFCIH YSTRNDYERE EYWDNNNGNN YKVDVVMDGF NDPFAAAA*

Amino Acid Sequence (or in FASTA format)

       1  MYIKAEQKPQ QFERKNEKLD RNKNQQLPDL ETDFKGYRVN SDLYNKERDG
      51  STEETLNSLK FLHKPQRVTQ MRANRFPEEE VQRNTDLNKR IFSAGNDENV
     101  DNESGWSKIA AAKNHTSVES LNGSTRPPFK IELPPLSPKS TVPKSFQAEY
     151  PEAKSPGNDM NFEYDEEILI PFAPPVYKKS GELLKSSLKR RSKSLPTTPG
     201  IRSGNGVQAR DGSPMLIRSK SVHFDQAAPV KYFAEDESPI NVNKTEQHDN
     251  CLSFKHKPVN LMVDPEEETK MLSSGLETTS IDDDLTTVAP KGFAHPAKIS
     301  NPNNGKGTNN TKLRKSKRFQ NLLKNRTDMP PSKSNKKFVN GGGAHEISDR
     351  NSKNYHVVGL YSKNFPILSN KNPKSLKLNI FINLSQNKKV FLQELSLYIH
     401  RDNNYFSNSS SFYNIPNSHN GNDCNGVAKG YNAGCTRLIA GRILVKNIFY
     451  DKRVVVRYTW DSWRTTHEVE CVYISDGDGI LPGTNMDIFH FIIDDVSKVD
     501  PRGKLEFCIH YSTRNDYERE EYWDNNNGNN YKVDVVMDGF NDPFAAAA*

external links for Gip2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gip2p

1)	Tu J, et al. (1996) Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4199-206
2)	Williams-Hart T, et al. (2002) Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Genetics 160(4):1423-37
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41