HOM3/YER052C Protein Information Help

Standard Name Hom3p 1
Systematic Name Yer052cp
Alias Bor1p , Sil4p , Thr3p 2
ORF Classification Verified
Description Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis (3, 4, 5, 6)
Name Description HOMoserine requiring 4, 7
Experimental Data
Molecules/cell 48100 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 527
Molecular Weight (Da) 58,109
Isoelectric Point (pI) 6.64

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hom3p (InterPro)
Physical Interactions There are 22 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012578C | P10869
MIPS: YER052C
NCBI: 113559 | 171693 | 603285 | 6320893 | NP_010972.1
GenBank/EMBL/DDBJ: DAA07708.1 | J03526 | U18796
External Classifications EC: 2.7.2.4 [Aspartate kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MPMDFQPTSS HSNWVVQKFG GTSVGKFPVQ IVDDIVKHYS KPDGPNNNVA
      51  VVCSARSSYT KAEGTTSRLL KCCDLASQES EFQDIIEVIR QDHIDNADRF
     101  ILNPALQAKL VDDTNKELEL VKKYLNASKV LGEVSSRTVD LVMSCGEKLS
     151  CLFMTALCND RGCKAKYVDL SHIVPSDFSA SALDNSFYTF LVQALKEKLA
     201  PFVSAKERIV PVFTGFFGLV PTGLLNGVGR GYTDLCAALI AVAVNADELQ
     251  VWKEVDGIFT ADPRKVPEAR LLDSVTPEEA SELTYYGSEV IHPFTMEQVI
     301  RAKIPIRIKN VQNPLGNGTI IYPDNVAKKG ESTPPHPPEN LSSSFYEKRK
     351  RGATAITTKN DIFVINIHSN KKTLSHGFLA QIFTILDKYK LVVDLISTSE
     401  VHVSMALPIP DADSLKSLRQ AEEKLRILGS VDITKKLSIV SLVGKHMKQY
     451  IGIAGTMFTT LAEEGINIEM ISQGANEINI SCVINESDSI KALQCIHAKL
     501  LSERTNTSNQ FEHAIDERLE QLKRLGI*

external links for Hom3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Hom3p
1) Calderon, I.  (1992) Personal Communication, Mortimer Map Edition 11
2) Robichon-Szulmajster H, et al.  (1966) Genetic and biochemical studies of genes controlling the synthesis of threonine and methionine in Saccharomyces. Genetics 53(3):609-19
3) Mountain HA, et al.  (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7(8):781-803
4) Rafalski JA and Falco SC  (1988) Structure of the yeast HOM3 gene which encodes aspartokinase. J Biol Chem 263(5):2146-51
5) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
6) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
7) Rafalski JA and Falco SC  (1990) Structure of the yeast HOM3 gene which encodes aspartokinase. J Biol Chem 265(25):15346
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41