ACA1/YER045C Protein Information

Standard Name	Aca1p
Systematic Name	Yer045cp
ORF Classification	Verified
Description	ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication (1, 2, 3)
Name Description	ATF/CREB Activator 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	489
Molecular Weight (Da)	54,592
Isoelectric Point (pI)	8.09

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aca1p (InterPro)
Physical Interactions	There are 14 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AC99 \| P39970 MIPS: YER045C NCBI: 398364425 \| 603278 \| 730013 \| NP_010964.3 GenBank/EMBL/DDBJ: DAA07700.1 \| U18796

Amino Acid Sequence (or in FASTA format)
1 MDYKHNFATS PDSFLDGRQN PLLYTDFLSS NKELIYKQPS GPGLVDSAYN 51 FHHQNSLHDR SVQENLGPMF QPFGVDISHL PITNPPIFQS SLPAFDQPVY 101 KRRISISNGQ ISQLGEDLET VENLYNCQPP ILSSKAQQNP NPQQVANPSA 151 AIYPSFSSNE LQNVPQPHEQ ATVIPEAAPQ TGSKNIYAAM TPYDSNIKLN 201 IPAVAATCDI PSATPSIPSG DSTMNQAYIN MQLRLQAQMQ TKAWKNAQLN 251 VHPCTPASNS SVSSSSSCQN INDHNIENQS VHSSISHGVN HHTVNNSCQN 301 AELNISSSLP YESKCPDVNL THANSKPQYK DATSALKNNI NSEKDVHTAP 351 FSSMHTTATF QIKQEARPQK IENNTAGLKD GAKAWKRARL LERNRIAASK 401 CRQRKKMSQL QLQREFDQIS KENTMMKKKI ENYEKLVQKM KKISRLHMQE 451 CTINGGNNSY QSLQNKDSDV NGFLKMIEEM IRSSSLYDE*

Amino Acid Sequence (or in FASTA format)

       1  MDYKHNFATS PDSFLDGRQN PLLYTDFLSS NKELIYKQPS GPGLVDSAYN
      51  FHHQNSLHDR SVQENLGPMF QPFGVDISHL PITNPPIFQS SLPAFDQPVY
     101  KRRISISNGQ ISQLGEDLET VENLYNCQPP ILSSKAQQNP NPQQVANPSA
     151  AIYPSFSSNE LQNVPQPHEQ ATVIPEAAPQ TGSKNIYAAM TPYDSNIKLN
     201  IPAVAATCDI PSATPSIPSG DSTMNQAYIN MQLRLQAQMQ TKAWKNAQLN
     251  VHPCTPASNS SVSSSSSCQN INDHNIENQS VHSSISHGVN HHTVNNSCQN
     301  AELNISSSLP YESKCPDVNL THANSKPQYK DATSALKNNI NSEKDVHTAP
     351  FSSMHTTATF QIKQEARPQK IENNTAGLKD GAKAWKRARL LERNRIAASK
     401  CRQRKKMSQL QLQREFDQIS KENTMMKKKI ENYEKLVQKM KKISRLHMQE
     451  CTINGGNNSY QSLQNKDSDV NGFLKMIEEM IRSSSLYDE*

external links for Aca1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Aca1p

1)	Garcia-Gimeno MA and Struhl K (2000) Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol 20(12):4340-9
2)	Spode I, et al. (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61