SAH1/YER043C Protein Information

Standard Name	Sah1p
Systematic Name	Yer043cp
ORF Classification	Verified
Description	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor (1, 2, 3)
Name Description	S-Adenosyl-l-Homocysteine hydrolase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	449
Molecular Weight (Da)	49,125
Isoelectric Point (pI)	6.2

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sah1p (InterPro)
Physical Interactions	There are 34 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013551C \| P39954 MIPS: YER043C NCBI: 398364417 \| 51013053 \| 603276 \| 730701 \| NP_010961.3 GenBank/EMBL/DDBJ: DAA07697.1 \| AY692801 \| U18796
External Classifications	EC: 3.3.1.1 [Adenosylhomocysteinase]

Amino Acid Sequence (or in FASTA format)
1 MSAPAQNYKI ADISLAAFGR KEIELAEHEM PGLMAIRKAY GDVQPLKGAR 51 IAGCLHMTIQ TAVLIETLVA LGAEVTWSSC NIYSTQDHAA AAIAASGVPV 101 FAWKGETEEE YLWCIEQQLF AFKDNKKLNL ILDDGGDLTT LVHEKHPEML 151 EDCFGLSEET TTGVHHLYRM VKEGKLKVPA INVNDSVTKS KFDNLYGCRE 201 SLVDGIKRAT DVMLAGKVAV VAGYGDVGKG CAAALRGMGA RVLVTEIDPI 251 NALQAAMEGY QVVTMEDASH IGQVFVTTTG CRDIINGEHF INMPEDAIVC 301 NIGHFDIEID VAWLKANAKE CINIKPQVDR YLLSSGRHVI LLANGRLVNL 351 GCATGHSSFV MSCSFSNQVL AQIALFKSND KSFREKHIEF QKTGPFEVGV 401 HVLPKILDEA VAKFHLGNLG VRLTKLSKVQ SEYLGIPEEG PFKADHYRY*

Amino Acid Sequence (or in FASTA format)

       1  MSAPAQNYKI ADISLAAFGR KEIELAEHEM PGLMAIRKAY GDVQPLKGAR
      51  IAGCLHMTIQ TAVLIETLVA LGAEVTWSSC NIYSTQDHAA AAIAASGVPV
     101  FAWKGETEEE YLWCIEQQLF AFKDNKKLNL ILDDGGDLTT LVHEKHPEML
     151  EDCFGLSEET TTGVHHLYRM VKEGKLKVPA INVNDSVTKS KFDNLYGCRE
     201  SLVDGIKRAT DVMLAGKVAV VAGYGDVGKG CAAALRGMGA RVLVTEIDPI
     251  NALQAAMEGY QVVTMEDASH IGQVFVTTTG CRDIINGEHF INMPEDAIVC
     301  NIGHFDIEID VAWLKANAKE CINIKPQVDR YLLSSGRHVI LLANGRLVNL
     351  GCATGHSSFV MSCSFSNQVL AQIALFKSND KSFREKHIEF QKTGPFEVGV
     401  HVLPKILDEA VAKFHLGNLG VRLTKLSKVQ SEYLGIPEEG PFKADHYRY*

external links for Sah1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Sah1p

1)	Shevchenko A, et al. (1996) Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci U S A 93(25):14440-5
2)	Kanehisa M, et al. (2002) The KEGG databases at GenomeNet. Nucleic Acids Res 30(1):42-6
3)	Tehlivets O, et al. (2004) S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. FEBS Lett 577(3):501-6