ARB1/YER036C Protein Information

Standard Name	Arb1p 1
Systematic Name	Yer036cp
ORF Classification	Verified
Description	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p (1)
Name Description	ATP-binding cassette protein involved in Ribosome Biogenesis 1

Experimental Data
Molecules/cell	17600 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	610
Molecular Weight (Da)	68,377
Isoelectric Point (pI)	6.48

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arb1p (InterPro)
Physical Interactions	There are 88 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053277 \| P40024 MIPS: YER036C NCBI: 603269 \| 6320874 \| 731453 \| NP_010953.1 GenBank/EMBL/DDBJ: DAA07689.1 \| U18796

Amino Acid Sequence (or in FASTA format)
1 MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR 51 EIKMMKLQQD KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS 101 GLELNYGRRY GLLGENGCGK STFLKALATR EYPIPEHIDI YLLDEPAEPS 151 ELSALDYVVT EAQHELKRIE DLVEKTILED GPESELLEPL YERMDSLDPD 201 TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA LFVKPTLLLL 251 DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK 301 LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV 351 KQAKSRQKIL DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF 401 HYESNPSENL YEHLNFGVDM DSRIALVGPN GVGKSTLLKI MTGELTPQSG 451 RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF VRDKYSNISQ DFQFWRGQLG 501 RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD EPTNGLDIPT 551 IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY 601 KNKLAKNVVL *

Amino Acid Sequence (or in FASTA format)

       1  MPPVSASKAK RDAKKAEREA KKAAAGKTIR KLGRKKEAAA EESEVDAAAR
      51  EIKMMKLQQD KDGLSDRVVT GVLSSLETSR DIKLSSVSLL FHGKVLIQDS
     101  GLELNYGRRY GLLGENGCGK STFLKALATR EYPIPEHIDI YLLDEPAEPS
     151  ELSALDYVVT EAQHELKRIE DLVEKTILED GPESELLEPL YERMDSLDPD
     201  TFESRAAIIL IGLGFNKKTI LKKTKDMSGG WKMRVALAKA LFVKPTLLLL
     251  DDPTAHLDLE ACVWLEEYLK RFDRTLVLVS HSQDFLNGVC TNMIDMRAQK
     301  LTAYGGNYDS YHKTRSELET NQMKQYNKQQ EEIQHIKKFI ASAGTYANLV
     351  KQAKSRQKIL DKMEADGLVQ PVVPDKVFSF RFPQVERLPP PVLAFDDISF
     401  HYESNPSENL YEHLNFGVDM DSRIALVGPN GVGKSTLLKI MTGELTPQSG
     451  RVSRHTHVKL GVYSQHSQDQ LDLTKSALEF VRDKYSNISQ DFQFWRGQLG
     501  RYGLTGEGQT VQMATLSEGQ RSRVVFALLA LEQPNVLLLD EPTNGLDIPT
     551  IDSLADAINE FNGGVVVVSH DFRLLDKIAQ DIFVVENKTA TRWDGSILQY
     601  KNKLAKNVVL *

external links for Arb1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Arb1p

1)	Dong J, et al. (2005) The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis. Mol Cell Biol 25(22):9859-73
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41