MIG3/YER028C Protein Information

Standard Name	Mig3p 1
Systematic Name	Yer028cp
ORF Classification	Verified
Description	Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Multicopy Inhibitor of Growth 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	394
Molecular Weight (Da)	43,119
Isoelectric Point (pI)	10.74

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mig3p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AC86 \| P39943 MIPS: YER028C NCBI: 603620 \| 6320866 \| 731446 \| NP_010945.1 \| NM_001178919.1 GenBank/EMBL/DDBJ: DAA07681.1 \| U18778

Amino Acid Sequence (or in FASTA format)
1 MNYLRDRFPP DNDQRPFRCE ICSRGFHRLE HKKRHGRTHT GEKPHKCTVQ 51 GCPKSFSRSD ELKRHLRTHT KGVQRRRIKS KGSRKTVVNT ATAAPTTFNE 101 NTGVSLTGIG QSKVPPILIS VAQNCDDVNI RNTGNNNGIV ETQAPAILVP 151 VINIPNDPHP IPSSLSTTSI TSIASVYPST SPFQYLKSGF PEDPASTPYV 201 HSSGSSLALG ELSSNSSIFS KSRRNLAAMS GPDSLSSSKN QSSASLLSQT 251 SHPSKSFSRP PTDLSPLRRI MPSVNTGDME ISRTVSVSSS SSSLTSVTYD 301 DTAAKDMGMG IFFDRPPVTQ KACRSNHKYK VNAVSRGRQH ERAQFHISGD 351 DEDSNVHRQE SRASNTSPNV SLPPIKSILR QIDNFNSAPS YFSK*

Amino Acid Sequence (or in FASTA format)

       1  MNYLRDRFPP DNDQRPFRCE ICSRGFHRLE HKKRHGRTHT GEKPHKCTVQ
      51  GCPKSFSRSD ELKRHLRTHT KGVQRRRIKS KGSRKTVVNT ATAAPTTFNE
     101  NTGVSLTGIG QSKVPPILIS VAQNCDDVNI RNTGNNNGIV ETQAPAILVP
     151  VINIPNDPHP IPSSLSTTSI TSIASVYPST SPFQYLKSGF PEDPASTPYV
     201  HSSGSSLALG ELSSNSSIFS KSRRNLAAMS GPDSLSSSKN QSSASLLSQT
     251  SHPSKSFSRP PTDLSPLRRI MPSVNTGDME ISRTVSVSSS SSSLTSVTYD
     301  DTAAKDMGMG IFFDRPPVTQ KACRSNHKYK VNAVSRGRQH ERAQFHISGD
     351  DEDSNVHRQE SRASNTSPNV SLPPIKSILR QIDNFNSAPS YFSK*

external links for Mig3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mig3p

1)	Dubacq C, et al. (2004) The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea. Mol Cell Biol 24(6):2560-72
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Lewis JA and Gasch AP (2012) Natural variation in the yeast glucose-signaling network reveals a new role for the mig3p transcription factor. G3 (Bethesda) 2(12):1607-12