PRO3/YER023W Protein Information

Standard Name	Pro3p
Systematic Name	Yer023wp
Alias	Ore2p 1
ORF Classification	Verified
Description	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis (2, 3)
Name Description	PROline requiring

Experimental Data
Molecules/cell	43500 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	286
Molecular Weight (Da)	30,132
Isoelectric Point (pI)	5.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pro3p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 28 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000132307 \| P32263 MIPS: YER023W NCBI: 172243 \| 398364353 \| 417541 \| 432970 \| 603615 \| NP_010940.3 GenBank/EMBL/DDBJ: DAA07676.1 \| M57886 \| U18778 \| X57338
External Classifications	EC: 1.5.1.2 [Pyrroline-5-carboxylate reductase]

Amino Acid Sequence (or in FASTA format)
1 MTYTLAILGC GVMGQALLSA IYNAPKAADE TAAAFYPSKI ITCNHDEPSA 51 QQVTDLVETF DESPNGIKVE STYGHNVSAV EEASVVLLGT KPFLAEEVLN 101 GVKSVIGGKL LISLAAGWTI DQLSQYTSTV CRVMTNTPAK YGYGCAVVSY 151 SADVSKEQKP LVNELISQVG KYVELPEKNM DAATALVGSG PAFVLLMLES 201 LMESGLKLGI PLQESKECAM KVLEGTVKMV EKSGAHPSVL KHQVCTPGGT 251 TIAGLCVMEE KGVKSGIING VEEAARVASQ LGQKKK*

Amino Acid Sequence (or in FASTA format)

       1  MTYTLAILGC GVMGQALLSA IYNAPKAADE TAAAFYPSKI ITCNHDEPSA
      51  QQVTDLVETF DESPNGIKVE STYGHNVSAV EEASVVLLGT KPFLAEEVLN
     101  GVKSVIGGKL LISLAAGWTI DQLSQYTSTV CRVMTNTPAK YGYGCAVVSY
     151  SADVSKEQKP LVNELISQVG KYVELPEKNM DAATALVGSG PAFVLLMLES
     201  LMESGLKLGI PLQESKECAM KVLEGTVKMV EKSGAHPSVL KHQVCTPGGT
     251  TIAGLCVMEE KGVKSGIING VEEAARVASQ LGQKKK*

external links for Pro3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pro3p

1)	Neuville P and Aigle M (1992) ore2, a mutation affecting proline biosynthesis in the yeast Saccharomyces cerevisiae, leads to a cdc phenotype. Mol Gen Genet 234(2):193-200
2)	Brandriss MC and Falvey DA (1992) Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase. J Bacteriol 174(11):3782-8
3)	Tomenchok DM and Brandriss MC (1987) Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. J Bacteriol 169(12):5364-72
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41