MNN1/YER001W Protein Information Help

Standard Name Mnn1p 1
Systematic Name Yer001wp
ORF Classification Verified
Description Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family (2, 3, 4)
Name Description MaNNosyltransferase
Experimental Data
Molecules/cell 1780 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 762
Molecular Weight (Da) 88,529
Isoelectric Point (pI) 7.23

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mnn1p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F2A0 | P39106
MIPS: YER001W
NCBI: 437726 | 603593 | 6320837 | 730039 | NP_010916.1 | NM_001178892.1
GenBank/EMBL/DDBJ: DAA07651.1 | L23753 | U18778
External Classifications EC: 2.4.1.- [Hexosyltransferases]
Amino Acid Sequence (or in FASTA format)
 
       1  MLALRRFILN QRSLRSCTIP ILVGALIIIL VLFQLVTHRN DALIRSSNVN
      51  STNKKTLKDA DPKVLIEAFG SPEVDPVDTI PVSPLELVPF YDQSIDTKRS
     101  SSWLINKKGY YKHFNELSLT DRCKFYFRTL YTLDDEWTNS VKKLEYSIND
     151  NEGVDEGKDA NGNPMDEKSE RLYRRKYDMF QAFERIRAYD RCFMQANPVN
     201  IQEIFPKSDK MSKERVQSKL IKTLNATFPN YDPDNFKKYD QFEFEHKMFP
     251  FINNFTTETF HEMVPKITSP FGKVLEQGFL PKFDHKTGKV QEYFKYEYDP
     301  SKTFWANWRD MSAKVAGRGI VLSLGSNQFP LAVKFIASLR FEGNTLPIQV
     351  VYRGDELSQE LVDKLIYAAR SPDFKPVENN YDNSTNVPQE IWFLDVSNTI
     401  HPKWRGDFGS YKSKWLVVLL NLLQEFVFLD IDAISYEKID NYFKTTEYQK
     451  TGTVFYRERA LRENVNERCI ARYETLLPRN LESKNFQNSL LIDPDHALNE
     501  CDNTLTTEEY IFKAFFHHRR QHQLEAGLFA VDKSKHTIPL VLAAMIHLAK
     551  NTAHCTHGDK ENFWLGFLAA GHTYALQGVY SGAIGDYVKK TDLNGKRQEA
     601  AVEICSGQIA HMSTDKKTLL WVNGGGTFCK HDNAAKDDWK KDGDFKKFKD
     651  QFKTFEEMEK YYYITPISSK YVILPDPKSD DWHRASAGAC GGYIWCATHK
     701  TLLKPYSYNH RTTHGELITL DEEQRLHIDA VNTVWSHANK DNTRSFTEEE
     751  IKELENSRHE QS*

external links for Mnn1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mnn1p
1) Raschke WC, et al.  (1973) Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants. J Biol Chem 248(13):4660-6
2) Graham TR, et al.  (1994) Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J Cell Biol 127(3):667-78
3) Lussier M, et al.  (1999) The KTR and MNN1 mannosyltransferase families of Saccharomyces cerevisiae. Biochim Biophys Acta 1426(2):323-34
4) Yip CL, et al.  (1994) Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins. Proc Natl Acad Sci U S A 91(7):2723-7
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41